Skeletal muscle mitochondrial ATP production rate and walking performance in peripheral arterial disease

Askew, Christopher, Barker, Glenn, Green, Anita, Green, Simon, Hou, Xiang-Yu, & Walker, Philip (2002) Skeletal muscle mitochondrial ATP production rate and walking performance in peripheral arterial disease. Clinical Physiology and Functional Imaging, 22(3), pp. 226-232.

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This study tested the hypotheses that skeletal muscle mitochondrial ATP production rate (MAPR) is impaired in patients with peripheral arterial disease (PAD) and that it relates positively to their walking performances. Seven untrained patients, eight exercise-trained patients and 11 healthy controls completed a maximal walking test and had muscle sampled from the gastrocnemius medialis muscle. Muscle was analysed for its MAPR in the presence of pyruvate, palmitoyl-L-carnitine or both, as well as citrate synthase (CS) activity. MAPRs were not different between untrained PAD and controls. In contrast, MAPRs (pyruvate) were significantly higher in trained PAD vs. controls. MAPR (pyruvate combinations) was also significantly higher in trained than untrained PAD muscle. MAPR and CS activity were highly correlated with walking performance in patients, but not in controls. These data do not support the hypothesis that isolated mitochondria are functionally impaired in PAD and demonstrate that the muscle mitochondrial capacity to oxidize carbohydrate is positively related to walking performance in these patients.

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22 citations in Web of Science®

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ID Code: 21810
Item Type: Journal Article
Refereed: Yes
ISSN: 1475-0961
Divisions: Current > Research Centres > Centre for Health Research
Current > QUT Faculties and Divisions > Faculty of Health
Deposited On: 17 Jun 2009 12:58
Last Modified: 16 Aug 2012 22:52

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