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Kallikrein-Related Peptidase (KLK) family mRNA variants and protein isoforms in hormone-related cancers : do they have a function?

Tan, Olivia, Whitbread, Astrid, Clements, Judith, & Dong, Ying (2006) Kallikrein-Related Peptidase (KLK) family mRNA variants and protein isoforms in hormone-related cancers : do they have a function? Biological Chemistry, 387(6), pp. 697-705.

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Abstract

The kallikrein-related peptidase (KLK) gene family of 15 serine proteases encodes many proteins, including prostate specific antigen (PSA or KLK3), that are well described and/or are potential biomarkers for hormone-related cancers. Variant mRNA transcripts produced by alternative splicing, polyadenylation or AUG sites, or intron retention have been found for each of the KLK genes. The predicted protein for many of these alternative transcripts is different from that of the classical kallikrein-related peptidases and would not be an active serine protease. The majority of these novel protein isoforms have not been studied in vivo. The possible function(s) of the variant transcripts/protein isoforms and potential roles that they may play in hormone-related cancers are still unknown and are the focus of this short review.

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27 citations in Web of Science®

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ID Code: 21901
Item Type: Journal Article
Keywords: mRNA Splicing, Nuclear Localisation, Serine Protease, Transcriptome
DOI: 10.1515/BC.2006.088
ISSN: 1431-6730
Subjects: Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > BIOCHEMISTRY AND CELL BIOLOGY (060100) > Biochemistry and Cell Biology not elsewhere classified (060199)
Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > GENETICS (060400) > Gene Expression (incl. Microarray and other genome-wide approaches) (060405)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Funding:
Deposited On: 17 Jun 2009 23:00
Last Modified: 09 Apr 2014 22:21

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