Multiple Genotypes of Chlamydia Pneumoniae identified in Human Carotid Plaque

Cochrane, Melanie, Gibbs, Harry, Timms, Peter, & Walker, Philip (2005) Multiple Genotypes of Chlamydia Pneumoniae identified in Human Carotid Plaque. Microbiology, 151(7), pp. 2285-2290.

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Abstract

Chlamydia pneumoniae is an obligate intracellular respiratory pathogen that causes 10 % of community-acquired pneumonia and has been associated with cardiovascular disease. Both whole-genome sequencing and specific gene typing suggest that there is relatively little genetic variation in human isolates of C. pneumoniae. To date, there has been little genomic analysis of strains from human cardiovascular sites. The genotypes of C. pneumoniae present in human atherosclerotic carotid plaque were analysed and several polymorphisms in the variable domain 4 (VD4) region of the outer-membrane protein-A (ompA) gene and the intergenic region between the ygeD and uridine kinase (ygeD-urk) genes were found. While one genotype was identified that was the same as one reported previously in humans (respiratory and cardiovascular), another genotype was found that was identical to a genotype from non-human sources (frog/koala).

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13 citations in Web of Science®

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ID Code: 22351
Item Type: Journal Article
Additional Information: Articles free to read on journal website after 12 months
Keywords: chlamydia, Heart disease, Bacteriology
DOI: 10.1099/mic.0.27781-0
ISSN: 1350-0872
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > CARDIOVASCULAR MEDICINE AND HAEMATOLOGY (110200) > Cardiology (incl. Cardiovascular Diseases) (110201)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > MEDICAL MICROBIOLOGY (110800) > Medical Bacteriology (110801)
Divisions: Past > QUT Faculties & Divisions > Faculty of Science and Technology
Deposited On: 17 Jun 2009 13:11
Last Modified: 05 Feb 2015 06:08

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