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Use of a quantitative gene expression assay based on micro-array techniques and a mathematical model for the investigation of chlamydial generation time

McElwain, D. L. S., Wilson, D. P., Mathews, S., Pettitt, A. N., & Wan, C. (2004) Use of a quantitative gene expression assay based on micro-array techniques and a mathematical model for the investigation of chlamydial generation time. Bulletin of Mathematical Biology, 66(3), pp. 523-537.

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Abstract

Chlamydia is an important pathogen which possesses a unique developmental cycle. We used real-time PCR technology to measure gene transcript levels in Chlamydia trachomatis strain L2. By measuring 16S rRNA transcript levels, and developing a mathematicalmodel of the chlamydial developmental cycle fitting the data, we predict an average generation time of approximately 2.6 h. Additionally, potentially this modelling also provides the foundation for the application of emerging micro-array technology in which identification of the gene signals that trigger a chlamydial body to start replicating or transform to its infectious form can be made possible.

Impact and interest:

14 citations in Scopus
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14 citations in Web of Science®

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ID Code: 22424
Item Type: Journal Article
DOI: 10.1016/j.bulm.2003.09.001
ISSN: 0092-8240
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Past > Schools > School of Life Sciences
Past > Schools > Mathematical Sciences
Copyright Owner: Copyright 2004 Academic Press Ltd
Deposited On: 17 Jun 2009 23:12
Last Modified: 29 Feb 2012 23:03

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