Voltammetric determination of chlorpromazine hydrochloride and promethazine hydrochloride with the use of multivariate calibration

Kokot, Serge, Ni, Yongnian, & Wang, li (2001) Voltammetric determination of chlorpromazine hydrochloride and promethazine hydrochloride with the use of multivariate calibration. Analytica Chimica Acta, 439(1), pp. 159-168.

View at publisher

Abstract

The voltammetric behavior of antipsychotic drugs, such as, chlorpromazine hydrochloride and promethazine hydrochloride has been investigated at a glassy carbon electrode in Britton–Robinson buffer of pH 9. It was found by applying the differential pulse stripping voltammetry (DPSV) that both chlorpromazine hydrochloride and promethazine hydrochloride had well formed oxidation voltammetric waves, with the peak potential for chlorpromazine hydrochloride at 620 mV, and for the two peaks of promethazine hydrochloride at 444 and 668 mV. The calibrations were linear for chlorpromazine hydrochloride and promethazine hydrochloride in the concentration ranges of 0.05–1.2 and 0.1–1 mg l−1, respectively. However, the voltammetric peaks of these two drugs, seriously overlap and it is difficult to determine them individually from a response of a drug mixture. In this work, a method for the simultaneous determination of these two drugs is proposed, and is based on their oxidation at the glassy carbon electrode. The interpretation of the complex voltammograms is achieved with the aid of chemometric methods, such as, classical least squares (CLS), principal component regression (PCR) and partial least squares (PLS). The proposed method was applied to determine these two drugs in a set of synthetic mixtures and blood samples, and in general, satisfactory results were obtained.

Impact and interest:

103 citations in Scopus
Search Google Scholar™
94 citations in Web of Science®

Citation counts are sourced monthly from Scopus and Web of Science® citation databases.

These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.

Citations counts from the Google Scholar™ indexing service can be viewed at the linked Google Scholar™ search.

ID Code: 22652
Item Type: Journal Article
Refereed: Yes
DOI: 10.1016/S0003-2670(01)01038-8
ISSN: 0003-2670
Divisions: Past > QUT Faculties & Divisions > Faculty of Science and Technology
Deposited On: 17 Jun 2009 13:19
Last Modified: 17 May 2017 01:20

Export: EndNote | Dublin Core | BibTeX

Repository Staff Only: item control page