Urinary Levels of Substance P and its Metabolites are not Increased in Interstitial Cystitis
Campbell, D, Clements, Judith, Dwyer, P. L., Rosmilia, A, & Tenis, N. (2001) Urinary Levels of Substance P and its Metabolites are not Increased in Interstitial Cystitis. BJU International, 87(1), pp. 35-38.
Objectives: To determine whether interstitial cystitis is associated with the increased release of substance P from the bladder wall into urine, by measuring urinary excretion rates of substance P and its metabolites in women with interstitial cystitis and in a control group of women with stress incontinence and normal bladder function.
Patients and methods: Catheter urine was collected from 13 patients and 10 controls during a water diuresis (≈ 10 mL/min) before and after instilling the bladder with 100 mL of water. The contribution of the bladder wall to urinary substance P peptides was assessed by measuring the change in substance P peptide levels after 2 min of bladder stasis before and after instillation.
Results: Absolute substance P excretion rates were similar in patients with interstitial cystitis and controls; 2 min of bladder stasis reduced the substance P excretion rate (P = 0.03) and increased the excretion rate of substance P metabolites (P = 0.01).
Conclusions: The release of substance P from the bladder wall was not increased in patients with interstitial cystitis.
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|Item Type:||Journal Article|
|Divisions:||Past > QUT Faculties & Divisions > Faculty of Science and Technology|
|Copyright Owner:||Copyright 2001 BJU International|
|Deposited On:||17 Jun 2009 13:21|
|Last Modified:||18 May 2016 05:58|
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