Urinary Levels of Substance P and its Metabolites are not Increased in Interstitial Cystitis

Campbell, D, Clements, Judith, Dwyer, P. L., Rosmilia, A, & Tenis, N. (2001) Urinary Levels of Substance P and its Metabolites are not Increased in Interstitial Cystitis. BJU International, 87(1), pp. 35-38.

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Objectives: To determine whether interstitial cystitis is associated with the increased release of substance P from the bladder wall into urine, by measuring urinary excretion rates of substance P and its metabolites in women with interstitial cystitis and in a control group of women with stress incontinence and normal bladder function.

Patients and methods: Catheter urine was collected from 13 patients and 10 controls during a water diuresis (≈ 10 mL/min) before and after instilling the bladder with 100 mL of water. The contribution of the bladder wall to urinary substance P peptides was assessed by measuring the change in substance P peptide levels after 2 min of bladder stasis before and after instillation.

Results: Absolute substance P excretion rates were similar in patients with interstitial cystitis and controls; 2 min of bladder stasis reduced the substance P excretion rate (P = 0.03) and increased the excretion rate of substance P metabolites (P = 0.01).

Conclusions: The release of substance P from the bladder wall was not increased in patients with interstitial cystitis.

Impact and interest:

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3 citations in Web of Science®

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ID Code: 22720
Item Type: Journal Article
Refereed: Yes
DOI: 10.1046/j.1464-410x.2001.00990.x
ISSN: 1464-4096
Divisions: Past > QUT Faculties & Divisions > Faculty of Science and Technology
Copyright Owner: Copyright 2001 BJU International
Deposited On: 17 Jun 2009 13:21
Last Modified: 18 May 2016 05:58

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