The role of kallikrein-related peptidases in prostate cancer : potential involvement in an epithelial to mesenchymal transition
Whitbread, Astrid, Veveris-Lowe, Tara, Lawrence, Mitchell, Nicol, David , & Clements, Judith (2006) The role of kallikrein-related peptidases in prostate cancer : potential involvement in an epithelial to mesenchymal transition. Biological Chemistry, 387(6), pp. 707-714.
Several members of the kallikrein-related peptidase family of serine proteases have proteolytic activities that may affect cancer progression; however, the in vivo significance of these activities remains uncertain. We have demonstrated that expression of PSA or KLK4, but not KLK2, in PC-3 prostate cancer cells changed the cellular morphology from epithelial to spindle-shaped, markedly reduced E-cadherin expression, increased vimentin expression and increased cellular migration. These changes are indicative of an epithelial to mesenchymal transition (EMT), a process important in embryonic development and cancer progression. The potential novel role of kallikrein-related peptidases in this process is the focus of this brief review.
Impact and interest:
Citation countsare sourced monthly fromand citation databases.
These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.
Citations counts from theindexing service can be viewed at the linked Google Scholar™ search.
|Item Type:||Journal Article|
|Keywords:||E-cadherin, Epithelial-Mesenchymal Transition, Prostate Cancer, Prostate-Specific Antigen, Kallikrein|
|Subjects:||Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > BIOCHEMISTRY AND CELL BIOLOGY (060100) > Cellular Interactions (incl. Adhesion Matrix Cell Wall) (060106)|
Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > BIOCHEMISTRY AND CELL BIOLOGY (060100) > Enzymes (060107)
|Divisions:||Current > QUT Faculties and Divisions > Faculty of Health|
Current > Institutes > Institute of Health and Biomedical Innovation
|Copyright Owner:||Copyright 2006 Walter de Gruyter GmbH & Co. KG|
|Deposited On:||17 Jun 2009 23:27|
|Last Modified:||26 Jul 2013 11:21|
Repository Staff Only: item control page