The role of kallikrein-related peptidases in prostate cancer : potential involvement in an epithelial to mesenchymal transition
Whitbread, Astrid, Veveris-Lowe, Tara, Lawrence, Mitchell, Nicol, David, & Clements, Judith (2006) The role of kallikrein-related peptidases in prostate cancer : potential involvement in an epithelial to mesenchymal transition. Biological Chemistry, 387(6), pp. 707-714.
Several members of the kallikrein-related peptidase family of serine proteases have proteolytic activities that may affect cancer progression; however, the in vivo significance of these activities remains uncertain. We have demonstrated that expression of PSA or KLK4, but not KLK2, in PC-3 prostate cancer cells changed the cellular morphology from epithelial to spindle-shaped, markedly reduced E-cadherin expression, increased vimentin expression and increased cellular migration. These changes are indicative of an epithelial to mesenchymal transition (EMT), a process important in embryonic development and cancer progression. The potential novel role of kallikrein-related peptidases in this process is the focus of this brief review.
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|Item Type:||Journal Article|
|Keywords:||E-cadherin, Epithelial-Mesenchymal Transition, Prostate Cancer, Prostate-Specific Antigen, Kallikrein|
|Subjects:||Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > BIOCHEMISTRY AND CELL BIOLOGY (060100) > Cellular Interactions (incl. Adhesion Matrix Cell Wall) (060106)|
Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > BIOCHEMISTRY AND CELL BIOLOGY (060100) > Enzymes (060107)
|Divisions:||Current > QUT Faculties and Divisions > Faculty of Health|
Current > Institutes > Institute of Health and Biomedical Innovation
|Copyright Owner:||Copyright 2006 Walter de Gruyter GmbH & Co. KG|
|Deposited On:||17 Jun 2009 23:27|
|Last Modified:||26 Jul 2013 11:21|
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