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The role of kallikrein-related peptidases in prostate cancer : potential involvement in an epithelial to mesenchymal transition

Whitbread, Astrid, Veveris-Lowe, Tara, Lawrence, Mitchell, Nicol, David, & Clements, Judith (2006) The role of kallikrein-related peptidases in prostate cancer : potential involvement in an epithelial to mesenchymal transition. Biological Chemistry, 387(6), pp. 707-714.

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Abstract

Several members of the kallikrein-related peptidase family of serine proteases have proteolytic activities that may affect cancer progression; however, the in vivo significance of these activities remains uncertain. We have demonstrated that expression of PSA or KLK4, but not KLK2, in PC-3 prostate cancer cells changed the cellular morphology from epithelial to spindle-shaped, markedly reduced E-cadherin expression, increased vimentin expression and increased cellular migration. These changes are indicative of an epithelial to mesenchymal transition (EMT), a process important in embryonic development and cancer progression. The potential novel role of kallikrein-related peptidases in this process is the focus of this brief review.

Impact and interest:

20 citations in Scopus
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16 citations in Web of Science®

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ID Code: 22875
Item Type: Journal Article
Keywords: E-cadherin, Epithelial-Mesenchymal Transition, Prostate Cancer, Prostate-Specific Antigen, Kallikrein
DOI: 10.1515/BC.2006.089
ISSN: 1431-6730
Subjects: Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > BIOCHEMISTRY AND CELL BIOLOGY (060100) > Cellular Interactions (incl. Adhesion Matrix Cell Wall) (060106)
Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > BIOCHEMISTRY AND CELL BIOLOGY (060100) > Enzymes (060107)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2006 Walter de Gruyter GmbH & Co. KG
Deposited On: 17 Jun 2009 23:27
Last Modified: 26 Jul 2013 11:21

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