The Expanded Human Kallikrein (KLK) gene family : genomic organisation, tissue specific expression and potential functions

Clements, Judith, Hooper, John D., Dong, Ying, & Harvey, Tracey (2005) The Expanded Human Kallikrein (KLK) gene family : genomic organisation, tissue specific expression and potential functions. Biological Chemistry, 382(1), pp. 5-14.

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The tissue kallikreins are serine proteases encoded by highly conserved multigene families. The rodent kallikrein (KLK) families are particularly large, consisting of 13 26 genes clustered in one chromosomal locus. It has been recently recognised that the human KLK gene family is of a similar size (15 genes) with the identification of another 12 related genes (KLK4-KLK15) within and adjacent to the original human KLK locus (KLK1-3) on chromosome 19q13.4. The structural organisation and size of these new genes is similar to that of other KLK genes except for additional exons encoding 5 or 3 untranslated regions. Moreover, many of these genes have multiple mRNA transcripts, a trait not observed with rodent genes. Unlike all other kallikreins, the KLK4-KLK15 encoded proteases are less related (25–44%) and do not contain a conventional kallikrein loop. Clusters of genes exhibit high prostatic (KLK2-4, KLK15) or pancreatic (KLK6-13) expression, suggesting evolutionary conservation of elements conferring tissue specificity. These genes are also expressed, to varying degrees, in a wider range of tissues suggesting a functional involvement of these newer human kallikrein proteases in a diverse range of physiological processes.

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87 citations in Web of Science®
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ID Code: 23349
Item Type: Journal Article
Refereed: Yes
DOI: 10.1515/BC.2001.002
ISSN: 1431-6730
Divisions: Past > QUT Faculties & Divisions > Faculty of Science and Technology
Copyright Owner: Copyright 2005 Walter de Gruyter
Copyright Statement: The final publication is available at
Deposited On: 17 Jun 2009 13:51
Last Modified: 29 Jul 2013 23:59

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