Reducing the global burden of depression : population level analysis of intervention cost-effectiveness in 14 world regions

Ayuso-Mateos, Jose Luis, Chisholm, Dan, Sanderson, Kristy, & Saxena, Shekhar (2004) Reducing the global burden of depression : population level analysis of intervention cost-effectiveness in 14 world regions. British Journal of Psychiatry, 184(5), pp. 393-403.

View at publisher (open access)


International evidence on the cost and effects of interventions for reducing the global burden of depression remain scarce.

Aims: To estimate the population-level cost-effectiveness of evidence-based depression interventions and their contribution towards reducing current burden.

Method: Primary-care-based depression interventions were modelled at the level of whole populations in 14 epidemiological subregions of the world. Total population-level costs (in international dollars or I$) and effectiveness (disability adjusted life years (DALYs) averted) were combined to form average and incremental cost-effectiveness ratios.

Results: Evaluated interventions have the potential to reduce the current burden of depression by 10–30%. Pharmacotherapy with older antidepressant drugs, with or without proactive collaborative care, are currently more cost-effective strategies than those using newer antidepressants, particularly in lower-income subregions.

Conclusions: Even in resource-poor regions, each DALYaverted by efficient depression treatments in primary care costs less than 1 year of average per capita income, making such interventions a cost-effective use of health resources. However, current levels of burden can only be reduced significantlyif there is a substantialincrease substantial increase intreatment coverage.

Impact and interest:

157 citations in Scopus
Search Google Scholar™
138 citations in Web of Science®

Citation counts are sourced monthly from Scopus and Web of Science® citation databases.

These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.

Citations counts from the Google Scholar™ indexing service can be viewed at the linked Google Scholar™ search.

ID Code: 23452
Item Type: Journal Article
Refereed: Yes
DOI: 10.1192/bjp.184.5.393
ISSN: 0007-1250
Divisions: Current > Research Centres > Centre for Health Research
Current > QUT Faculties and Divisions > Faculty of Health
Deposited On: 17 Jun 2009 13:55
Last Modified: 12 Jul 2013 04:54

Export: EndNote | Dublin Core | BibTeX

Repository Staff Only: item control page