CD8(+) T Lymphocyte-Mediated Loss Of Marginal Metallophilic Macrophages Following Infection With Plasmodium Chabaudi Chabaudi AS

Beattie, Lynette, Engwerda, Christian, Good, Michael, & Wykes, Michelle (2006) CD8(+) T Lymphocyte-Mediated Loss Of Marginal Metallophilic Macrophages Following Infection With Plasmodium Chabaudi Chabaudi AS. The Journal of Immunology, 177, pp. 2518-2526.

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The splenic architecture is essential for the quick resolution of a primary infection with Plasmodium. A critical component of this architecture is the marginal zone (MZ), an area of the spleen that separates the reticuloendothelial red pulp of the spleen from the lymphoid white pulp compartment. There are two unique macrophage populations found in the MZ: MZ macrophages (MZM) found on the outer border of the MZ, and marginal metallophilic macrophages (MMM) found on the inner border, adjacent to the white pulp. We investigated the homeostasis of MMM and MZM following infection with Plasmodium chabaudi and demonstrated that a complete loss of both MMM and MZM occurred by the time of peak parasitemia, 8 days after infection. The loss was not induced by up-regulation of the inflammatory cytokines TNF or IFN-γ. In contrast, following only CD8+ T cell depletion (not dendritic cell), MMM but not MZM were retained, implicating CD8+ T cells in the P. chabaudi-induced loss of MMM. Retention of MMM occurred in mice deficient in CD95, CD95-ligand, and perforin, indicating that these signals are involved in the death pathway of MMM. These data have significant implications for the understanding of the immune-mediated pathology of the spleen as a result of infection with Plasmodium.

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ID Code: 23532
Item Type: Journal Article
Refereed: Yes
Additional Information: Articles free to read on journal website after 12 months
ISSN: 0022-1767
Divisions: Past > QUT Faculties & Divisions > Faculty of Science and Technology
Deposited On: 17 Jun 2009 13:58
Last Modified: 19 May 2017 04:53

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