Acquisition of pure-phase diffusion spectra using oscillating-gradient spin echo
Momot, Konstantin I., Kuchel, Philip W., & Chapman, Bogdan E. (2005) Acquisition of pure-phase diffusion spectra using oscillating-gradient spin echo. Journal of Magnetic Resonance, 176(2), pp. 151-159.
Oscillating-gradient spin echo (OGSE) diffusion experiments have long been used to measure the short-time apparent diffusion coefficient, Dapp (t), in the presence of restricted diffusion, as well as the spectrum of the slow-motion velocity autocorrelation function. In this work, we focus on two previously unexplored aspects of OGSE experiments: convection compensation and acquisition of pure-phase diffusion spectra in the presence of homonuclear scalar couplings. We demonstrate that convection compensation afforded by single-echo OGSE compares well with that in double-echo convection-compensated PGSE experiments. We also show that, in the presence of homonuclear scalar couplings, setting the OGSE echo time to 1/2J enables acquisition of pure-phase diffusion spectra and yields more reliable D estimates than mixed-phase PGSE or OGSE spectra. Pure-phase OGSE acquisition is also compatible with measurements of the apparent diffusion coefficient at an arbitrary diffusion time. These features of OGSE can be valuable in diffusion measurements of scalar-coupled small-molecule probes in cellular and other heterogeneous systems.
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|Item Type:||Journal Article|
|Keywords:||Nuclear magnetic resonance, Convection compensation, NMR diffusion and flow measurements, Modified, cosine gradient pulse, Apparent diffusion coefficient, Homonuclear scalar couplings|
|Divisions:||Past > QUT Faculties & Divisions > Faculty of Science and Technology|
|Copyright Owner:||Copyright 2005 Elsevier|
|Copyright Statement:||Reproduced in accordance with the copyright policy of the publisher.|
|Deposited On:||09 Dec 2005 00:00|
|Last Modified:||29 Feb 2012 13:20|
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