Pulsed field gradient nuclear magnetic resonance as a tool for studying drug delivery systems

Momot, Konstantin I. & Kuchel, Philip W. (2003) Pulsed field gradient nuclear magnetic resonance as a tool for studying drug delivery systems. Concepts in Magnetic Resonance. Part A, 19A(2), pp. 51-64.

View at publisher

Abstract

Pulsed field gradient (PFG) nuclear magnetic resonance (NMR) is a versatile method for studying molecular transport and exchange in solution. Stejskal-Tanner diffusion plots can be used to distinguish between chemical species even in the absence of chemical shift or T1 resolution, provided that certain conditions are satisfied. This can be used advantageously in colloidal drug delivery systems containing two drug populations, free and bound, which often differ only by their diffusion coefficients. We discuss the conditions required for the resolution of the two pools in Stejskal-Tanner plots, as well as the effects of chemical exchange. We also present two practical examples of this analysis: surfactant micelles containing the general anesthetic propofol and lipid/water liquid crystalline mesophase vehicles (cubosomes).

Impact and interest:

44 citations in Scopus
Search Google Scholar™
45 citations in Web of Science®

Citation counts are sourced monthly from Scopus and Web of Science® citation databases.

These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.

Citations counts from the Google Scholar™ indexing service can be viewed at the linked Google Scholar™ search.

Full-text downloads:

1,138 since deposited on 30 Nov 2005
90 in the past twelve months

Full-text downloads displays the total number of times this work’s files (e.g., a PDF) have been downloaded from QUT ePrints as well as the number of downloads in the previous 365 days. The count includes downloads for all files if a work has more than one.

ID Code: 2672
Item Type: Journal Article
Refereed: Yes
Additional URLs:
Keywords: Nuclear magnetic resonance, nonionic surfactant micelles, monoolein cubosomes and vesicles, pulsed field gradient spin, echo (PGSE) NMR spectroscopy, diffusion, molecular association and chemical exchange, drug delivery vehicles
DOI: 10.1002/cmr.a.10092
ISSN: 1546-6086
Divisions: Past > QUT Faculties & Divisions > Faculty of Science and Technology
Past > Schools > School of Physical & Chemical Sciences
Copyright Owner: Copyright 2003 John Wiley & Sons
Copyright Statement: The definite version is available on publication at www3.interscience.wiley.com
Deposited On: 30 Nov 2005 00:00
Last Modified: 06 Jul 2015 04:36

Export: EndNote | Dublin Core | BibTeX

Repository Staff Only: item control page