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Anisotropy of spin relaxation of water protons in cartilage and tendon

Momot, Konstantin I., Pope, James M., & Wellard, R. Mark (2010) Anisotropy of spin relaxation of water protons in cartilage and tendon. NMR in Biomedicine, 23(3), pp. 313-324.

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Abstract

Transverse spin relaxation rates of water protons in articular cartilage and tendon depend on the orientation of the tissue relative to the applied static magnetic field. This complicates the interpretation of magnetic resonance images of these tissues. At the same time, relaxation data can provide information about their organisation and microstructure. We present a theoretical analysis of the anisotropy of spin relaxation of water protons observed in fully hydrated cartilage. We demonstrate that the anisotropy of transverse relaxation is due almost entirely to intramolecular dipolar coupling modulated by a specific mode of slow molecular motion: the diffusion of water molecules in the hydration shell of a collagen fibre around the fibre, such that the molecular director remains perpendicular to the fibre. The theoretical anisotropy arising from this mechanism follows the “magic-angle” dependence observed in magnetic-resonance measurements of cartilage and tendon and is in good agreement with the available experimental results. We discuss the implications of the theoretical findings for MRI of ordered collagenous tissues.

Impact and interest:

7 citations in Scopus
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6 citations in Web of Science®

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ID Code: 27317
Item Type: Journal Article
Keywords: cartilage, Redfield spin relaxation theory, magnetic resonance imaging, tendon, rotational diffusion propagator, nuclear magnetic resonance
DOI: 10.1002/nbm.1466
ISSN: 0952-3480
Subjects: Australian and New Zealand Standard Research Classification > PHYSICAL SCIENCES (020000) > OTHER PHYSICAL SCIENCES (029900) > Medical Physics (029903)
Australian and New Zealand Standard Research Classification > PHYSICAL SCIENCES (020000) > OTHER PHYSICAL SCIENCES (029900) > Biological Physics (029901)
Divisions: Past > QUT Faculties & Divisions > Faculty of Science and Technology
Copyright Owner: Copyright 2010 John Wiley & Sons
Copyright Statement: The definitive version is available at www3.interscience.wiley.com
Deposited On: 11 Sep 2009 07:29
Last Modified: 01 Mar 2012 00:09

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