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Comparison of 3D finite element analysis derived stiffness and BMD to determine the failure load of the excised proximal femur

Langton, Christian, Pisharody, S., & Keyak, J. H. (2009) Comparison of 3D finite element analysis derived stiffness and BMD to determine the failure load of the excised proximal femur. Medical Engineering & Physics, 31(6), pp. 668-672.

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Abstract

Introduction: Bone mineral density (BMD) is currently the preferred surrogate for bone strength in clinical practice. Finite element analysis (FEA) is a computer simulation technique that can predict the deformation of a structure when a load is applied, providing a measure of stiffness (Nmm−1). Finite element analysis of X-ray images (3D-FEXI) is a FEA technique whose analysis is derived froma single 2D radiographic image.

Methods: 18 excised human femora had previously been quantitative computed tomography scanned, from which 2D BMD-equivalent radiographic images were derived, and mechanically tested to failure in a stance-loading configuration. A 3D proximal femur shape was generated from each 2D radiographic image and used to construct 3D-FEA models.

Results: The coefficient of determination (R2%) to predict failure load was 54.5% for BMD and 80.4% for 3D-FEXI.

Conclusions: This ex vivo study demonstrates that 3D-FEXI derived from a conventional 2D radiographic image has the potential to significantly increase the accuracy of failure load assessment of the proximal femur compared with that currently achieved with BMD. This approach may be readily extended to routine clinical BMD images derived by dual energy X-ray absorptiometry.

Crown Copyright © 2009 Published by Elsevier Ltd on behalf of IPEM. All rights reserved

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ID Code: 27527
Item Type: Journal Article
Additional URLs:
Keywords: BMD, Bone Strength, Failure Load, Finite Element Analysis, Proximal Femur
DOI: 10.1016/j.medengphy.2008.12.007
ISSN: 1350-4533
Subjects: Australian and New Zealand Standard Research Classification > INFORMATION AND COMPUTING SCIENCES (080000) > ARTIFICIAL INTELLIGENCE AND IMAGE PROCESSING (080100) > Simulation and Modelling (080110)
Australian and New Zealand Standard Research Classification > PHYSICAL SCIENCES (020000) > OTHER PHYSICAL SCIENCES (029900) > Medical Physics (029903)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > HUMAN MOVEMENT AND SPORTS SCIENCE (110600) > Biomechanics (110601)
Australian and New Zealand Standard Research Classification > INFORMATION AND COMPUTING SCIENCES (080000) > ARTIFICIAL INTELLIGENCE AND IMAGE PROCESSING (080100) > Image Processing (080106)
Divisions: Past > QUT Faculties & Divisions > Faculty of Science and Technology
Current > Institutes > Institute of Health and Biomedical Innovation
Past > Schools > School of Physical & Chemical Sciences
Copyright Owner: Copyright 2009 Elsevier Ltd on behalf of IPEM.
Deposited On: 25 Sep 2009 10:31
Last Modified: 29 Feb 2012 23:59

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