Strategies for zonal cartilage repair using hydrogels

Klein, Travis J., Rizzi, Simone C., Reichert, Johannes C., Georgi, Nicole, Malda, Jos, Schuurman, Wouter, Crawford, Ross W., & Hutmacher, Dietmar W. (2009) Strategies for zonal cartilage repair using hydrogels. Macromolecular Bioscience, 9, pp. 1-10.

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Articular cartilage is a highly hydrated tissue with depth-dependent cellular and matrix properties that provide low-friction load bearing in joints. However, the structure and function are frequently lost and there is insufficient repair response to regenerate high-quality cartilage. Several hydrogel-based tissue-engineering strategies have recently been developed to form constructs with biomimetic zonal variations to improve cartilage repair. Modular hydrogel systems allow for systematic control over hydrogel properties, and advanced fabrication techniques allow for control over construct organization. These technologies have great potential to address many unanswered questions involved in prescribing zonal properties to tissue-engineered constructs for cartilage repair.

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64 citations in Scopus
59 citations in Web of Science®
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ID Code: 27541
Item Type: Journal Article
Refereed: Yes
Keywords: biological applications of polymers, biomimetic, cartilage , hydrogels, tissue engineering
DOI: 10.1002/mabi.200900176
ISSN: 1616-5187
Subjects: Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Biomaterials (090301)
Divisions: Past > QUT Faculties & Divisions > Faculty of Built Environment and Engineering
Past > QUT Faculties & Divisions > Faculty of Science and Technology
Current > Institutes > Institute of Health and Biomedical Innovation
Past > Schools > School of Life Sciences
Past > Schools > School of Engineering Systems
Deposited On: 27 Oct 2009 00:35
Last Modified: 29 Feb 2012 13:57

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