The role of periosteum : a neglected aspect of osteoporosis

Xiao, Yin, Fan, Wei, Bouwense, Stefan AW, & Crawford, Ross W. (2009) The role of periosteum : a neglected aspect of osteoporosis. In Mattingly, Bilar E. & Pillare, Albert C. (Eds.) Osteoporosis : Etiology, Diagnosis, and Treatment. Nova Science Publishers, Inc., Hauppauge, New York, pp. 235-249.

View at publisher


Most current studies on the pathogenesis of osteoporosis emphasize the bone metabolic activities occurring on endosteal surfaces, whereas the periosteal aspect is somewhat neglected. In terms of bone physiology, periosteum plays a determining role in de novo cortical bone formation and cortical bone expansion through periosteum is the most efficient way of increasing bone strength against fractures. Despite the important role of periosteum in the pathogenesis and treatment of osteoporosis, little is known about the structural and cellular features of periosteum in osteoporosis. This chapter will focus on the major changes occurring in the periosteum of osteoporosis and possible implications of these changes in the pathogenesis of osteoporosis. The changes identified in the periosteum of osteoporosis are mainly located in the metaphyseal compartment, which include: (a) much thicker and more cellular cambial layer; (b) increased number of TRAP (tartrate resistant acid phosphatase), VEGF (vascular endothelial growth factor) cells and the degree of vascularization; and (c) enhanced expression of sympathetic nerve fibers. The structural and cellular changes of osteoporotic periosteum indicate that periosteum plays an important role in the cortical bone resorption in metaphyseal areas and this pathological process may be regulated by the sympathetic nervous system.

Impact and interest:

Citation counts are sourced monthly from Scopus and Web of Science® citation databases.

These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.

Citations counts from the Google Scholar™ indexing service can be viewed at the linked Google Scholar™ search.

ID Code: 28116
Item Type: Book Chapter
Keywords: osteoporosis, periosteum, tartrate resistant acid phosphatase, vascular endonthelial growth factor, metaphyseal
ISBN: 9781606923979
Divisions: Past > QUT Faculties & Divisions > Faculty of Built Environment and Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Past > Schools > School of Engineering Systems
Copyright Owner: Copyright 2009 Nova Science Publishers, Inc.
Deposited On: 22 Oct 2009 03:15
Last Modified: 10 Aug 2016 15:52

Export: EndNote | Dublin Core | BibTeX

Repository Staff Only: item control page