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Evaluation of the in vitro bioactivity of bioceramics

Wu , Chengtie & Xiao, Yin (2009) Evaluation of the in vitro bioactivity of bioceramics. Bone and Tissue Regeneration Insights, 2, pp. 25-29.

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Abstract

Two common methods have been used to evaluate the in vitro bioactivity of bioceramics for the application of bone repair. One is to evaluate the ability of apatite formation by soaking ceramics in simulated body fluids (SBF); the other method is to evaluate the effect of ceramics on osteogenic differentiation using cell experiments. Both methods have their own drawbacks in evaluating the in vitro bioactivity of bioceramics. In this commentary paper we review the application of both methods in bioactivity of bioceramics and conclude that (i) SBF method is an efficient method to investigate the in vitro bioactivity of silicate-based bioceramics, (ii) cellular bioactivity of bioceramics should be investigated by evaluating their stimulatory ability using standard bioceramics as controls; and (iii) the combination of these two methods to evaluate the in vitro bioactivity of bioceramics can improve the screening efficiency for the selection of bioactive ceramics for bone regeneration.

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ID Code: 28122
Item Type: Journal Article
Keywords: in vitro bioactivity, SBF, cel experiments, bioceramics, apatite formation, osteogenic differentiation
ISSN: 1179-061X
Subjects: Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Biomaterials (090301)
Divisions: Past > QUT Faculties & Divisions > Faculty of Built Environment and Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Past > Schools > School of Engineering Systems
Copyright Owner: Copyright 2009 the authors.
Deposited On: 23 Oct 2009 10:58
Last Modified: 10 Jun 2010 00:05

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