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Composite electrospun scaffolds for engineering tubular bone grafts

Hutmacher, Dietmar W., Ekaputra, Andrew K., Zhou, Yefang, & Cool, Simon (2009) Composite electrospun scaffolds for engineering tubular bone grafts. Tissue Engineering Part A.

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Abstract

In this study, poly (e-caprolactone) [PCL] and its collagen composite blend (PCL=Col) were fabricated to scaffolds using electrospinning method. Incorporated collagen was present on the surface of the fibers, and it modulated the attachment and proliferation of pig bone marrow mesenchymal cells (pBMMCs). Osteogenic differentiation markers were more pronounced when these cells were cultured on PCL=Col fibrous meshes, as determined by immunohistochemistry for collagen type I, osteopontin, and osteocalcin. Matrix mineralization was observed only on osteogenically induced PCL=Col constructs. Long bone analogs were created by wrapping osteogenic cell sheets around the PCL=Col meshes to form hollow cylindrical cell-scaffold constructs. Culturing these constructs under dynamic conditions enhanced bone-like tissue formation and mechanical strength.We conclude that electrospun PCL=Col mesh is a promising material for bone engineering applications. Its combination with osteogenic cell sheets offers a novel and promising strategy for engineering of tubular bone analogs.

Impact and interest:

33 citations in Scopus
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27 citations in Web of Science®

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ID Code: 28138
Item Type: Journal Article
Additional URLs:
Keywords: electrospinning, scaffold, tissue engineering, bone, polymer
DOI: 10.1089/ten.tea.2009.0186
ISSN: 1937-3341
Subjects: Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Biomaterials (090301)
Divisions: Past > QUT Faculties & Divisions > Faculty of Built Environment and Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Past > Schools > School of Engineering Systems
Copyright Owner: Copyright 2009 Mary Ann Liebert, Inc.
Deposited On: 26 Oct 2009 12:34
Last Modified: 01 Mar 2012 00:06

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