Evaluating tear film stability in the human eye with high-speed videokeratoscopy

Iskander, D. Robert, Collins, Michael J., & Davis, Brett A. (2005) Evaluating tear film stability in the human eye with high-speed videokeratoscopy. IEEE Transactions on Biomedical Engineering, 52(11), pp. 1939-1949.


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High-speed videokeratoscopy (HSV) is an emerging technology that has the potential to acquire information on the dynamics of corneal topography and tear-film behavior. We show that the surface regularity and asymmetry indices, which are traditionally used for characterizing the stability of precorneal tear film, have limitations in the context of HSV because they are highly sensitive to natural ocular microfluctuations. To overcome this problem, we propose a new microfluctuation-independent surface indicator. It is based on the root-mean-square of the error of the parametric model fit to the surface. Further, we develop techniques for estimating the tear film build-up and break-up times. The tear film build-up time estimator is based on the proposed RMS fit surface indicator while the tear film break-up time estimator is derived directly from a set of consecutive HSV digital images, without the need for estimating the resulting corneal surface.

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ID Code: 2820
Item Type: Journal Article
Refereed: Yes
Keywords: Corneal topography, tear film build, up and break, up times, videokeratography
DOI: 10.1109/TBME.2005.856253
ISSN: 0018-9294
Subjects: Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Biomedical Engineering not elsewhere classified (090399)
Australian and New Zealand Standard Research Classification > PHYSICAL SCIENCES (020000) > OTHER PHYSICAL SCIENCES (029900) > Synchrotrons; Accelerators; Instruments and Techniques (029904)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300) > Vision Science (111303)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300) > Optical Technology (111302)
Divisions: Past > QUT Faculties & Divisions > Faculty of Built Environment and Engineering
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2005 IEEE
Copyright Statement: Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from the IEEE.
Deposited On: 04 Jan 2006 00:00
Last Modified: 29 Feb 2012 13:15

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