Establishment of a preclinical ovine model for tibial segmental bone defect repair by applying bone tissue engineering strategies

Reichert, Johannes C., Epari, Devakara R., Wullschleger, Martin E., Saifzadeh, Siamak, Steck, Roland, Lienau, Jasmin, Sommerville, Scott, Dickinson, Ian C., Schutz, Michael A., Duda, Georg N., & Hutmacher, Dietmar W. (2009) Establishment of a preclinical ovine model for tibial segmental bone defect repair by applying bone tissue engineering strategies. Tissue Engineering Part B Reviews.

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Currently, well-established clinical therapeutic approaches for bone reconstruction are restricted to the transplantation of autografts and allografts, and the implantation of metal devices or ceramic-based implants to assist bone regeneration. Bone grafts possess osteoconductive and osteoinductive properties, however they are limited in access and availability and associated with donor site morbidity, haemorrhage, risk of infection, insufficient transplant integration, graft devitalisation, and subsequent resorption resulting in decreased mechanical stability. As a result, recent research focuses on the development of alternative therapeutic concepts. The field of tissue engineering has emerged as an important approach to bone regeneration. However, bench to bedside translations are still infrequent as the process towards approval by regulatory bodies is protracted and costly, requiring both comprehensive in vitro and in vivo studies. The subsequent gap between research and clinical translation, hence commercialization, is referred to as the ‘Valley of Death’ and describes a large number of projects and/or ventures that are ceased due to a lack of funding during the transition from product/technology development to regulatory approval and subsequently commercialization. One of the greatest difficulties in bridging the Valley of Death is to develop good manufacturing processes (GMP) and scalable designs and to apply these in pre-clinical studies. In this article, we describe part of the rationale and road map of how our multidisciplinary research team has approached the first steps to translate orthopaedic bone engineering from bench to bedside byestablishing a pre-clinical ovine critical-sized tibial segmental bone defect model and discuss our preliminary data relating to this decisive step.

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33 citations in Scopus
29 citations in Web of Science®
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ID Code: 28221
Item Type: Journal Article
Refereed: Yes
Additional URLs:
Keywords: segmental bone defect, animal model, tissue engineering
DOI: 10.1089/ten.TEB.2009.0455
ISSN: 1937-3368
Subjects: Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Biomaterials (090301)
Divisions: Past > QUT Faculties & Divisions > Faculty of Built Environment and Engineering
Past > QUT Faculties & Divisions > Faculty of Science and Technology
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2009 Mary Ann Liebert Inc. Publishers
Deposited On: 27 Oct 2009 01:28
Last Modified: 09 Jul 2017 11:01

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