The Queensland study of melanoma : Environmental and genetic associations (Q-MEGA); Study design, baseline characteristics, and repeatability of phenotype and sun exposure measures
Baxter, Amanda J. , Hughes, Maria Celia , Kvaskoff, Marina , Siskind, Victor, Shekar, Sri , Aitken, Joanne F., Green, Adele C., Duffy, David L. , Hayward, Nicholas K. , Martin, Nicholas G. , & Whiteman, David C. (2008) The Queensland study of melanoma : Environmental and genetic associations (Q-MEGA); Study design, baseline characteristics, and repeatability of phenotype and sun exposure measures. Twin Research and Human Genetics, 11(2), pp. 183-196.
Cutaneous malignant melanoma (CMM) is a major health issue in Queensland, Australia, which has the world’s highest incidence. Recent molecular and epidemiologic studies suggest that CMM arises through multiple etiological pathways involving gene-environment interactions. Understanding the potential mechanisms leading to CMM requires larger studies than those previously conducted. This article describes the design and baseline characteristics of Q-MEGA, the Queensland Study of Melanoma: Environmental and Genetic Associations, which followed up 4 population-based samples of CMM patients in Queensland, including children, adolescents, men aged over 50, and a large sample of adult cases and their families, including twins. Q-MEGA aims to investigate the roles of genetic and environmental factors, and their interaction, in the etiology of melanoma. Three thousand, four hundred and seventy-one participants took part in the follow-up study and were administered a computer-assisted telephone interview in 2002-2005. Updated data on environmental and phenotypic risk factors, and 2777 blood samples were collected from interviewed participants as well as a subset of relatives. This study provides a large and well-described population-based sample of CMM cases with follow-up data. Characteristics of the cases and repeatability of sun exposure and phenotype measures between the baseline and the follow-up surveys, from 6 to 17 years later, are also described.
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|Item Type:||Journal Article|
|Additional Information:||Victor Siskind is employed as an Adjunct Professor by the Centre for Accident Research and Road Safety - Queensland, Queensland University of Technology.|
|Keywords:||melanoma, environmental factors, genetic factors, Queensland|
|Subjects:||Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > PUBLIC HEALTH AND HEALTH SERVICES (111700) > Epidemiology (111706)|
|Deposited On:||04 Dec 2009 09:47|
|Last Modified:||11 Aug 2011 04:17|
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