Major depressive disorder and nutritional medicine : a review of monotherapies and adjuvant treatments

Kavanagh, David J., Schoendorfer, Niikee, & Sarris, Jerome (2009) Major depressive disorder and nutritional medicine : a review of monotherapies and adjuvant treatments. Nutrition Reviews, 67(3), pp. 125-131.

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A literature review was conducted to examine the evidence for nutritional interventions in depression. It revealed a number of significant conclusions. Interestingly, more positive clinical trials were found to support adjuvant, rather than monotherapeutic, use of nutrients to treat depression. Much evidence exists in the area of adjuvant application of folic acid, S-adenosyl-methionine, omega-3, and L-tryptophan with antidepressants. Current evidence does not support omega-3 as an effective monotherapy to treat depression. However, this may be due, at least in part, to olive oil being used as the control intervention, some studies using docosahexaenoic acid alone or a higher docosahexaenoic acid to eicosapentaenoic acid ratio, and significant heterogeneity regarding depressive populations. Nevertheless, adjunctive prescription of omega-3 with antidepressants, or in people with dietary deficiency, may be beneficial. Inositol lacks evidence as an effective antidepressant and cannot be currently recommended. Evidence on the use of L-trytophan for depression is inconclusive and additional studies utilizing a more robust methodology are required.

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31 citations in Web of Science®
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ID Code: 28562
Item Type: Journal Article
Refereed: Yes
Keywords: Depression, Folic acid, L-tryptophan, Nutrition, Omega 3, SAMe
DOI: 10.1111/j.1753-4887.2009.00180.x
ISSN: 0029-6643
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > NUTRITION AND DIETETICS (111100)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Psychology & Counselling
Copyright Owner: Copyright 2009 International Life Sciences Institute
Deposited On: 11 Nov 2009 05:05
Last Modified: 29 Feb 2012 14:07

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