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Effects of inoculating dose on the kinetics of Chlamydia muridarum genital infection in female mice

Carey, Alison J., Cunningham, Kelly A., Hafner, Louise M., Timms, Peter, & Beagley, Kenneth W. (2009) Effects of inoculating dose on the kinetics of Chlamydia muridarum genital infection in female mice. Immunology and Cell Biology, 87, pp. 337-343.

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Abstract

Chlamydia trachomatis infections have been implicated in problems such as pelvic inflammatory disease and infertility in females. Although there are some studies examining the kinetics of ascending infection, there is limited information on the kinetics of pathology development and cellular infiltrate into the reproductive tissues in relation to the effects of inoculating dose, and a better understanding of these is needed. The murine model of female genital tract Chlamydia muridarum infection is frequently used as a model of human C. trachomatis reproductive tract infection. To investigate the kinetics of ascending genital infection and associated pathology development, female BALB/c mice were intravaginally infected with C. muridarum at doses ranging from 5102 to 2.6106 inclusion forming units. We found that the inoculating dose affects the course of infection and the ascension of bacteria, with the highest dose ascending rapidly to the oviducts. By comparison, the lowest dose resulted in the greatest bacterial load in the lower reproductive tract. Interestingly, we found that the dose did not significantly affect inflammatory cell infiltrate in the various regions. Overall, this data show the effects of infectious dose on the kinetics of ascending chlamydial infection and associated inflammatory infiltration in BALB/c mice.

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ID Code: 28772
Item Type: Journal Article
Keywords: Chlamydial infection, Female Reproductive Tract, Inflammation
DOI: 10.1038/icb.2009.3
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > MEDICAL MICROBIOLOGY (110800) > Medical Infection Agents (incl. Prions) (110802)
Divisions: Past > QUT Faculties & Divisions > Faculty of Science and Technology
Current > Institutes > Institute of Health and Biomedical Innovation
Past > Schools > School of Life Sciences
Copyright Owner: Copyright 2009 Australasian Society for Immunology/Nature Publishing Group
Deposited On: 25 Nov 2009 11:58
Last Modified: 29 Feb 2012 23:58

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