Ethyl-eicosapentaenoic acid in first-episode psychosis : a 1H-MRS study

Berger, Gregor E., Wood, Stephen J., Wellard, R. Mark, Proffitt, Tina M., McConchie, Mirabel, Amminger, G. Paul, Jackson, Graeme D., Velakoulis, Dennis, Pantelis, Christos, & McGorry, Patrick D. (2008) Ethyl-eicosapentaenoic acid in first-episode psychosis : a 1H-MRS study. Neuropsychopharmacology, 33(10), pp. 2467-2473.

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Ethyl-eicosapentaenoic acid (E-EPA) is an omega-3 fatty acid that has been used in a range of neuropsychiatric conditions with some benefits. However, its mechanism of action is unknown. Here, we investigate its effects on in vivo brain metabolism in first-episode psychosis (FEP). Proton magnetic resonance spectroscopy at 3 T was performed in the temporal lobes of 24 FEP patients before and after 12 weeks of treatment in the context of a larger double-blind, placebo-controlled E-EPA augmentation study. Treatment group effects for glutathione (F1,12=6.1, p=0.03), and a hemisphere-by-group interaction for glutamine/glutamate (F1,20=4.4, p=0.049) were found. Glutathione increased bilaterally and glutamate/glutamine increased in the left hemisphere following E-EPA administration. Improvement in negative symptoms correlated with metabolic brain changes, particularly glutathione (r=-0.57). These results suggest that E-EPA augmentation alters glutathione availability and modulates the glutamine/glutamate cycle in early psychosis, with some of the metabolic brain changes being correlated with negative symptom improvement. Larger confirmatory studies of these postulated metabolic brain effects of E-EPA are warranted.

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65 citations in Scopus
66 citations in Web of Science®
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ID Code: 28794
Item Type: Journal Article
Refereed: Yes
Keywords: Ethyl-eicosapentaenoic acid, Omega-3 Fatty Acids, Schizophrenia, Gluthatione, Astrocytes, (E-EPA)
DOI: 10.1038/sj.npp.1301628
ISSN: 0893-133X
Subjects: Australian and New Zealand Standard Research Classification > TECHNOLOGY (100000) > MEDICAL BIOTECHNOLOGY (100400)
Divisions: Past > QUT Faculties & Divisions > Faculty of Science and Technology
Past > Schools > School of Physical & Chemical Sciences
Copyright Owner: Copyright 2008 Nature Publishing Group
Deposited On: 06 Jan 2010 22:24
Last Modified: 29 Feb 2012 13:53

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