Ethyl-eicosapentaenoic acid in first-episode psychosis : a 1H-MRS study
Berger, Gregor E. , Wood, Stephen J. , Wellard, R. Mark, Proffitt, Tina M. , McConchie, Mirabel , Amminger, G. Paul , Jackson, Graeme D. , Velakoulis, Dennis , Pantelis, Christos , & McGorry, Patrick D. (2008) Ethyl-eicosapentaenoic acid in first-episode psychosis : a 1H-MRS study. Neuropsychopharmacology, 33(10), pp. 2467-2473.
Ethyl-eicosapentaenoic acid (E-EPA) is an omega-3 fatty acid that has been used in a range of neuropsychiatric conditions with some benefits. However, its mechanism of action is unknown. Here, we investigate its effects on in vivo brain metabolism in first-episode psychosis (FEP). Proton magnetic resonance spectroscopy at 3 T was performed in the temporal lobes of 24 FEP patients before and after 12 weeks of treatment in the context of a larger double-blind, placebo-controlled E-EPA augmentation study. Treatment group effects for glutathione (F1,12=6.1, p=0.03), and a hemisphere-by-group interaction for glutamine/glutamate (F1,20=4.4, p=0.049) were found. Glutathione increased bilaterally and glutamate/glutamine increased in the left hemisphere following E-EPA administration. Improvement in negative symptoms correlated with metabolic brain changes, particularly glutathione (r=-0.57). These results suggest that E-EPA augmentation alters glutathione availability and modulates the glutamine/glutamate cycle in early psychosis, with some of the metabolic brain changes being correlated with negative symptom improvement. Larger confirmatory studies of these postulated metabolic brain effects of E-EPA are warranted.
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|Item Type:||Journal Article|
|Keywords:||Ethyl-eicosapentaenoic acid, Omega-3 Fatty Acids, Schizophrenia, Gluthatione, Astrocytes, (E-EPA)|
|Subjects:||Australian and New Zealand Standard Research Classification > TECHNOLOGY (100000) > MEDICAL BIOTECHNOLOGY (100400)|
|Divisions:||Past > QUT Faculties & Divisions > Faculty of Science and Technology|
Past > Schools > School of Physical & Chemical Sciences
|Copyright Owner:||Copyright 2008 Nature Publishing Group|
|Deposited On:||07 Jan 2010 08:24|
|Last Modified:||29 Feb 2012 23:53|
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