Age-related development of a refractive index plateau in the human lens : evidence for a distinct nucleus

Augusteyn, Robert C., Jones, Catherine E., & Pope, James M. (2008) Age-related development of a refractive index plateau in the human lens : evidence for a distinct nucleus. Clinical and Experimental Optometry, 91(3), pp. 296-301.

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The human lens comprises two distinct regions in which the refractive index changes at different rates. The periphery contains a rapidly increasing refractive index gradient, which becomes steeper with age. The inner region contains a shallow gradient, which flattens with age, due to formation of a central plateau, of RI = 1.418, which reaches a maximum size of 7.0 × 3.05 mm around age 60 years. Formation of the plateau can be attributed to compression of fibre cells generated in prenatal life. Present in prenatal but not in postnatal fibre cells, γ-crystallin may play a role in limiting nuclear cell compression.

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12 citations in Scopus
14 citations in Web of Science®
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104 since deposited on 04 Dec 2009
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ID Code: 29067
Item Type: Journal Article
Refereed: Yes
Additional URLs:
Keywords: Gradient, Lens, Growth, Nucleus, Refraction, RI Plateau
DOI: 10.1111/j.1444-0938.2007.00244.x
ISSN: 0816-4622
Divisions: Past > QUT Faculties & Divisions > Faculty of Science and Technology
Past > Schools > School of Physical & Chemical Sciences
Copyright Owner: Copyright 2008 Optometrists Association Australia
Copyright Statement: The definitive version is available at
Deposited On: 04 Dec 2009 00:47
Last Modified: 29 Feb 2012 13:51

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