Age-related development of a refractive index plateau in the human lens : evidence for a distinct nucleus
Augusteyn, Robert C., Jones, Catherine E., & Pope, James M. (2008) Age-related development of a refractive index plateau in the human lens : evidence for a distinct nucleus. Clinical and Experimental Optometry, 91(3), pp. 296-301.
The human lens comprises two distinct regions in which the refractive index changes at different rates. The periphery contains a rapidly increasing refractive index gradient, which becomes steeper with age. The inner region contains a shallow gradient, which flattens with age, due to formation of a central plateau, of RI = 1.418, which reaches a maximum size of 7.0 × 3.05 mm around age 60 years. Formation of the plateau can be attributed to compression of fibre cells generated in prenatal life. Present in prenatal but not in postnatal fibre cells, γ-crystallin may play a role in limiting nuclear cell compression.
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|Item Type:||Journal Article|
|Keywords:||Gradient, Lens, Growth, Nucleus, Refraction, RI Plateau|
|Divisions:||Past > QUT Faculties & Divisions > Faculty of Science and Technology
Past > Schools > School of Physical & Chemical Sciences
|Copyright Owner:||Copyright 2008 Optometrists Association Australia|
|Copyright Statement:||The definitive version is available at www3.interscience.wiley.com|
|Deposited On:||04 Dec 2009 00:47|
|Last Modified:||29 Feb 2012 13:51|
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