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Ghrelin gene-related peptides : multifunctional endocrine/autocrine modulators in health and disease

Seim, Inge, Amorim, Laura, Walpole, Carina, Carter, Shea, Chopin, Lisa K., & Herington, Adrian C. (2009) Ghrelin gene-related peptides : multifunctional endocrine/autocrine modulators in health and disease. Clinical And Experimental Pharmacology And Physiology.

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Abstract

Ghrelin is a multi-functional peptide hormone which affects various processes including growth hormone and insulin release, appetite regulation, gut motility, metabolism and cancer cell proliferation. Ghrelin is produced in the stomach and in other normal and pathological cell types. It may act as an endocrine or autocrine/paracrine factor. The ghrelin gene encodes a precursor protein, preproghrelin, from which ghrelin and other potentially active peptides are derived by alternative mRNA splicing and/or proteolytic processing. The metabolic role of the peptide obestatin, derived from the preproghrelin C-terminal region, is controversial. However, it has direct effects on cancer cell proliferation. The regulation of ghrelin expression and the mechanisms through which the peptide products arise are unclear. We have recently re-examined the organisation of the ghrelin gene and identified several novel exons and transcripts. One transcript, which lacks the ghrelin-coding region of preproghrelin, contains the coding sequence of obestatin. Furthermore, we have identified an overlapping gene on the antisense strand of ghrelin, GHRLOS, which generates transcripts that may function as non-coding regulatory RNAs or code for novel, short bioactive peptides. The identification of these novel ghrelin-gene related transcripts and peptides raises critical questions regarding their physiological function and their role in obesity, diabetes and cancer.

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11 citations in Scopus
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7 citations in Web of Science®

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ID Code: 29124
Item Type: Journal Article
Keywords: ghrelin, gene expression, hormone-dependent cancer, obestatin, GHSR
DOI: 10.1111/j.1440-1681.2009.05241.x
ISSN: 0305-1870
Subjects: Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > BIOCHEMISTRY AND CELL BIOLOGY (060100) > Biochemistry and Cell Biology not elsewhere classified (060199)
Divisions: Past > QUT Faculties & Divisions > Faculty of Science and Technology
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 07 Dec 2009 14:10
Last Modified: 01 Mar 2012 00:06

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