Event-related potential (ERP) correlates of impaired visuospatial memory in schizophrenia
Cameron, Allison , Geffen, Gina , Kavanagh, David J., Wright, Margie , McGrath, John J. , & Geffen, Laurie (2003) Event-related potential (ERP) correlates of impaired visuospatial memory in schizophrenia. Psychophysiology, 40(5), pp. 702-715.
Previous studies have reported that patients with schizophrenia demonstrate impaired performance during working memory (WM) tasks. The current study aimed to determine whether WM impairments in schizophrenia are accompanied by reduced slow wave (SW) activity during on-line maintenance of mnemonic information. Event-related potentials were obtained from patients with schizophrenia and well controls as they performed a visuospatial delayed response task. On 50% of trials, a distractor stimulus was introduced during the delay. Compared with controls, patients with schizophrenia produced less SW memory negativity, particularly over the right hemisphere, together with reduced frontal enhancement of SW memory negativity in response to distraction. The results indicate that patients with schizophrenia generate less maintenance phase neuronal activity during WM performance, especially under conditions of distraction.
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|Item Type:||Journal Article|
|Keywords:||Schizophrenia, Event-related potentials, Impaired visuospatial working memory, Slow wave, Maintenance, Distraction|
|Subjects:||Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > CLINICAL SCIENCES (110300) > Psychiatry (incl. Psychotherapy) (110319)|
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > PUBLIC HEALTH AND HEALTH SERVICES (111700) > Mental Health (111714)
|Divisions:||Current > QUT Faculties and Divisions > Faculty of Health|
Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Psychology & Counselling
|Deposited On:||09 Dec 2009 08:56|
|Last Modified:||01 Mar 2012 00:10|
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