Working memory correlates of three symptom clusters in schizophrenia

Cameron, Allison, Oram, Joanne, Geffen, Gina, Kavanagh, David J., McGrath, John J., & Geffen, Laurie (2002) Working memory correlates of three symptom clusters in schizophrenia. Psychiatry Research, 110(1), pp. 49-61.

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Examined whether discrete working memory deficits underlie positive, negative and disorganised symptoms of schizophrenia. 52 outpatients (mean age 37.5 yrs) with schizophrenia were studied using items drawn from the Positive and Negative Syndrome Scale (PANSS). Linear regression and correlational analyses were conducted to examine whether symptom dimension scores were related to performance on several tests of working memory function. Severity of negative symptoms correlated with reduced production of words during a verbal fluency task, impaired ability to hold letter and number sequences on-line and manipulate them simultaneously, reduced performance during a dual task, and compromised visuospatial working memory under distraction-free conditions. Severity of disorganisation symptoms correlated with impaired visuospatial working memory under conditions of distraction, failure of inhibition during a verbal fluency task, perseverative responding on a test of set-shifting ability, and impaired ability to judge the veracity of simple declarative statements. The present study provides evidence that the positive, negative and disorganised symptom dimensions of the PANSS constitute independent clusters, associated with unique patterns of working memory impairment.

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49 citations in Web of Science®
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ID Code: 29178
Item Type: Journal Article
Refereed: Yes
Keywords: Working memory deficits, Positive and negative disorganized symptoms, Schizophrenia
DOI: 10.1016/S0165-1781(02)00036-7
ISSN: 0165-1781
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 09 Dec 2009 00:13
Last Modified: 09 Jul 2017 18:01

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