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Tissue engineering of articular cartilage with biomimetic zones

Klein, Travis, Malda, Jos, Sah, Robert, & Hutmacher, Dietmar (2009) Tissue engineering of articular cartilage with biomimetic zones. Tissue Engineering, 15(2), pp. 143-157.

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Abstract

Articular cartilage damage is a persistent and increasing problem with the aging population, and treatments to achieve biological repair or restoration remain a challenge. Cartilage tissue engineering approaches have been investigated for over 20 years, but have yet to achieve the consistency and effectiveness for widespread clinical use. One of the potential reasons for this is that the engineered tissues do not have or establish the normal zonal organization of cells and extracellular matrix that appears critical for normal tissue function. A number of approaches are being taken currently to engineer tissue that more closely mimics the organization of native articular cartilage. This review focuses on the zonal organization of native articular cartilage, strategies being used to develop such organization, the reorganization that occurs after culture or implantation, and future prospects for the tissue engineering of articular cartilage with biomimetic zones.

Impact and interest:

81 citations in Scopus
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65 citations in Web of Science®

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ID Code: 29202
Item Type: Journal Article
Keywords: Cartilage, Scaffold, Hydrogel, Regenerative Medicine, Tissue Engineering
DOI: 10.1089/ten.teb.2008.0563
ISSN: 1937-3368
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > CLINICAL SCIENCES (110300) > Rheumatology and Arthritis (110322)
Australian and New Zealand Standard Research Classification > TECHNOLOGY (100000) > MEDICAL BIOTECHNOLOGY (100400) > Regenerative Medicine (incl. Stem Cells and Tissue Engineering) (100404)
Divisions: Past > QUT Faculties & Divisions > Faculty of Built Environment and Engineering
Past > QUT Faculties & Divisions > Faculty of Science and Technology
Current > Institutes > Institute of Health and Biomedical Innovation
Past > Schools > School of Life Sciences
Past > Schools > School of Engineering Systems
Deposited On: 10 Dec 2009 15:44
Last Modified: 29 Feb 2012 23:59

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