Deposition of combustion aerosols in the human respiratory tract : comparison of theoretical predictions with experimental data

Hofmann, W., Morawska, L., Winkler-Heil, R., & Moustafa, M. (2009) Deposition of combustion aerosols in the human respiratory tract : comparison of theoretical predictions with experimental data. Inhalation Toxicology, 21(14), pp. 1154-1164.

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 Total deposition of petrol, diesel and environmental tobacco smoke (ETS) aerosols in the human respiratory tract for nasal breathing conditions was computed for 14 nonsmoking volunteers, considering the specific anatomical and respiratory parameters of each volunteer and the specific size distribution for each inhalation experiment. Theoretical predictions were 34.6% for petrol, 24.0% for diesel, and 18.5% for ETS particles. Compared to the experimental results, predicted deposition values were consistently smaller than the measured data (41.4% for petrol, 29.6% for diesel, and 36.2% for ETS particles). The apparent discrepancy between experimental data on total deposition and modeling results may be reconciled by considering the non-spherical shape of the test aerosols by diameter-dependent dynamic shape factors to account for differences between mobility-equivalent and volume-equivalent or thermodynamic diameters. While the application of dynamic shape factors is able to explain the observed differences for petrol and diesel particles, additional mechanisms may be required for ETS particle deposition, such as the size reduction upon inspiration by evaporation of volatile compounds and/or condensation-induced restructuring, and, possibly, electrical charge effects.

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17 citations in Scopus
11 citations in Web of Science®
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ID Code: 29219
Item Type: Journal Article
Refereed: Yes
Additional URLs:
Keywords: Deposition, Combustion Aerosols, Respiratory Tract
DOI: 10.3109/08958370902806696
ISSN: 0895-8378
Subjects: Australian and New Zealand Standard Research Classification > EARTH SCIENCES (040000) > ATMOSPHERIC SCIENCES (040100) > Atmospheric Aerosols (040101)
Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > MICROBIOLOGY (060500) > Microbiology not elsewhere classified (060599)
Divisions: Past > QUT Faculties & Divisions > Faculty of Science and Technology
Current > Institutes > Institute of Health and Biomedical Innovation
Past > Schools > School of Physical & Chemical Sciences
Copyright Owner: Copyright 2009 Taylor & Francis
Deposited On: 09 Dec 2009 23:19
Last Modified: 29 Feb 2012 14:08

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