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Diffuse reflectance near infrared spectroscopy can distinguish normal from enzymatically digested cartilage

Brown, Cameron P., Bowden, Joshua, Rintoul, Llewellyn, Meder, Roger, Oloyede, Adekunle, & Crawford, Ross W. (2009) Diffuse reflectance near infrared spectroscopy can distinguish normal from enzymatically digested cartilage. Physics in Medicine and Biology, 54(18), pp. 5579-5594.

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Abstract

A non-destructive, diffuse reflectance near infrared spectroscopy (DR-NIRS)approach is considered as a potential tool for determining the component-level structural properties of articular cartilage. To this end, DR-NIRS was applied in vitro to detect structural changes, using principal component analysis as the statistical basis for characterization. The results show that this technique, particularly with first-derivative pretreatment, can distinguish normal, intact cartilage from enzymatically digested cartilage. Further, this paper establishes that the use of DR-NIRS enables the probing of the full depth of the uncalcified cartilage matrix, potentially allowing the assessment of degenerative changes in joint tissue, independent of the site of initiation of the osteoarthritic process.

Impact and interest:

13 citations in Scopus
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10 citations in Web of Science®

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273 since deposited on 27 Jan 2010
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ID Code: 29562
Item Type: Journal Article
Keywords: Freshwater, Climate Change, Water Provision, Infrastructure
DOI: 10.1088/0031-9155/54/18/015
ISSN: 0031-9155
Subjects: Australian and New Zealand Standard Research Classification > BUILT ENVIRONMENT AND DESIGN (120000) > URBAN AND REGIONAL PLANNING (120500) > Urban Analysis and Development (120507)
Divisions: Past > QUT Faculties & Divisions > Faculty of Built Environment and Engineering
Past > QUT Faculties & Divisions > Faculty of Science and Technology
Current > Institutes > Institute of Health and Biomedical Innovation
Past > Schools > School of Engineering Systems
Past > Schools > School of Physical & Chemical Sciences
Copyright Owner: Copyright 2009 Please consult the authors.
Deposited On: 27 Jan 2010 12:24
Last Modified: 01 Mar 2012 00:03

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