New findings with old drugs for osteoporosis

Doggrell, Sheila (2009) New findings with old drugs for osteoporosis. Expert Opinion on Pharmacotherapy, 10(3), pp. 513-516.

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Background : Postmenopausal osteoporosis is common and is associated with stooped posture, loss of height, back pain and fractures. Objectives/methods : This evaluation is of clinical outcome trials with tibolone (Long-Term Intervention of Fractures with Tibolone) and strontium ranelate (Spinal Osteoporosis Therapeutic Intervention) in postmenopausal osteoporosis. Results : Although the Long-Term Intervention of Fractures with Tibolone trial established that tibolone decreased the incidence of vertebral and non-vertebral fractures in postmenopausal osteoporosis, it also showed that tibolone caused a small increase in the incidence of stoke. The Spinal Osteoporosis Therapeutic Intervention trial established that strontium ranelate decreased the incidence of vertebral fractures, but had little effect on the incidence of non-vertebral fractures. Conclusions : As some of the bisphosphonates (alendronate, risedronate, zoledronic acid) have been shown to prevent hip fractures without increasing the incidence of stroke, they should be preferred to tibolone and strontium in the treatment of postmenopausal osteoporosis.

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1 citations in Scopus
1 citations in Web of Science®
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ID Code: 29623
Item Type: Journal Article
Refereed: Yes
Additional URLs:
Keywords: strontium ranelate, tibolone, postmenopausal osteoporosis, clinical trials
DOI: 10.1517/14656560802707887
ISSN: 1465-6566
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > PHARMACOLOGY AND PHARMACEUTICAL SCIENCES (111500) > Clinical Pharmacology and Therapeutics (111502)
Divisions: Past > QUT Faculties & Divisions > Faculty of Science and Technology
Past > Schools > School of Life Sciences
Copyright Owner: Copyright 2009 Informa Healthcare
Deposited On: 12 Jan 2010 21:32
Last Modified: 25 Mar 2015 03:00

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