Telcagepant is a new oral treatment for migraine
Doggrell, Sheila (2009) Telcagepant is a new oral treatment for migraine. Expert Opinion in Pharmacotherapy, 10(9), pp. 1523-1526.
Background : Migraine is a common cause of disability. Many subjects (30 – 40%) do not respond to the 5-HT 1B/1D agonists (the triptans) commonly used in the treatment of migraine attacks. Calcitonin gene-related protein (CGRP) receptor antagonism is a new approach to the treatment of migraine attacks. Objectives/methods : This evaluation is of a Phase III clinical trial comparing telcagepant, an orally active CGRP receptor antagonist, with zolmitriptan in subjects during an attack of migraine. Results : Telcagepant 300 mg has a similar efficacy to zolmitriptan in relieving pain, phonophobia, photophobia, and nausea. Telcagepant was better tolerated than zolmitriptan. Conclusions : The initial Phase III clinical trial results with telcagepant are promising but several further clinical trials are needed to determine the place of telcagepant in the treatment of migraine attacks
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|Item Type:||Journal Article|
|Keywords:||telcagepant, CGRP receptor antagonism, migraine attack, zolmitriptan|
|Subjects:||Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > PHARMACOLOGY AND PHARMACEUTICAL SCIENCES (111500) > Clinical Pharmacology and Therapeutics (111502)|
|Divisions:||Past > QUT Faculties & Divisions > Faculty of Science and Technology|
Past > Schools > School of Life Sciences
|Copyright Owner:||Copyright 2009 Informa Healthcare|
|Deposited On:||14 Jan 2010 09:50|
|Last Modified:||19 Jan 2012 15:38|
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