Telcagepant is a new oral treatment for migraine

Doggrell, Sheila (2009) Telcagepant is a new oral treatment for migraine. Expert Opinion in Pharmacotherapy, 10(9), pp. 1523-1526.

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Background : Migraine is a common cause of disability. Many subjects (30 – 40%) do not respond to the 5-HT 1B/1D agonists (the triptans) commonly used in the treatment of migraine attacks. Calcitonin gene-related protein (CGRP) receptor antagonism is a new approach to the treatment of migraine attacks. Objectives/methods : This evaluation is of a Phase III clinical trial comparing telcagepant, an orally active CGRP receptor antagonist, with zolmitriptan in subjects during an attack of migraine. Results : Telcagepant 300 mg has a similar efficacy to zolmitriptan in relieving pain, phonophobia, photophobia, and nausea. Telcagepant was better tolerated than zolmitriptan. Conclusions : The initial Phase III clinical trial results with telcagepant are promising but several further clinical trials are needed to determine the place of telcagepant in the treatment of migraine attacks

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2 citations in Scopus
2 citations in Web of Science®
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ID Code: 29663
Item Type: Journal Article
Refereed: Yes
Keywords: telcagepant, CGRP receptor antagonism, migraine attack, zolmitriptan
DOI: 10.1517/14656560902980236
ISSN: 1465-6566
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > PHARMACOLOGY AND PHARMACEUTICAL SCIENCES (111500) > Clinical Pharmacology and Therapeutics (111502)
Divisions: Past > QUT Faculties & Divisions > Faculty of Science and Technology
Copyright Owner: Copyright 2009 Informa Healthcare
Deposited On: 13 Jan 2010 23:50
Last Modified: 19 Jan 2012 05:38

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