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Telcagepant is a new oral treatment for migraine

Doggrell, Sheila (2009) Telcagepant is a new oral treatment for migraine. Expert Opinion in Pharmacotherapy, 10(9), pp. 1523-1526.

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Abstract

Background : Migraine is a common cause of disability. Many subjects (30 – 40%) do not respond to the 5-HT 1B/1D agonists (the triptans) commonly used in the treatment of migraine attacks. Calcitonin gene-related protein (CGRP) receptor antagonism is a new approach to the treatment of migraine attacks. Objectives/methods : This evaluation is of a Phase III clinical trial comparing telcagepant, an orally active CGRP receptor antagonist, with zolmitriptan in subjects during an attack of migraine. Results : Telcagepant 300 mg has a similar efficacy to zolmitriptan in relieving pain, phonophobia, photophobia, and nausea. Telcagepant was better tolerated than zolmitriptan. Conclusions : The initial Phase III clinical trial results with telcagepant are promising but several further clinical trials are needed to determine the place of telcagepant in the treatment of migraine attacks

Impact and interest:

2 citations in Scopus
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1 citations in Web of Science®

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ID Code: 29663
Item Type: Journal Article
Keywords: telcagepant, CGRP receptor antagonism, migraine attack, zolmitriptan
DOI: 10.1517/14656560902980236
ISSN: 1465-6566
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > PHARMACOLOGY AND PHARMACEUTICAL SCIENCES (111500) > Clinical Pharmacology and Therapeutics (111502)
Divisions: Past > QUT Faculties & Divisions > Faculty of Science and Technology
Past > Schools > School of Life Sciences
Copyright Owner: Copyright 2009 Informa Healthcare
Deposited On: 14 Jan 2010 09:50
Last Modified: 19 Jan 2012 15:38

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