Tesofensine : a novel potent weight loss medicine

Doggrell, Sheila (2009) Tesofensine : a novel potent weight loss medicine. Expert Opinion in Investigational Drugs, 18(7), pp. 1043-1046.

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Background: The incidence of obesity is increasing; this is of major concern, as obesity is associated with cardiovascular disease, stroke, type 2 diabetes, respiratory tract disease, and cancer. Objectives/methods: This evaluation is of a Phase II clinical trial with tesofensine in obese subjects. Results: After 26 weeks, tesofensine caused a significant weight loss, and may have a higher maximal ability to reduce weight than the presently available anti-obesity agents. However, tesofensine also increased blood pressure and heart rate, and may increase psychiatric disorders. Conclusions: It is encouraging that tesofensine 0.5 mg may cause almost double the weight loss observed with sibutramine or rimonabant. As tesofensine and sibutramine have similar pharmacological profiles, it would be of interest to compare the weight loss with tesofensine in a head-to-head clinical trial with sibutramine, to properly assess their comparative potency. Also, as teso fensine 0.5 mg increases heart rate, as well as increasing the incidence of adverse effects such as nausea, drug mouth, flatulence, insomnia, and depressed mode, its tolerability needs to be further evaluated in large Phase III clinical trials.

Impact and interest:

7 citations in Scopus
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6 citations in Web of Science®

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ID Code: 29667
Item Type: Journal Article
Refereed: Yes
Keywords: tesofensine, obesity, sibutramine, clinical trial
DOI: 10.1517/13543780902967632
ISSN: 1354-3784
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > PHARMACOLOGY AND PHARMACEUTICAL SCIENCES (111500) > Basic Pharmacology (111501)
Divisions: Past > QUT Faculties & Divisions > Faculty of Science and Technology
Past > Schools > School of Life Sciences
Copyright Owner: Copyright 2009 Informa Healthcare
Deposited On: 13 Jan 2010 23:05
Last Modified: 19 Jan 2012 05:38

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