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Anti-cancer activity of zoledronic acid in breast cancer

Doggrell, Sheila (2009) Anti-cancer activity of zoledronic acid in breast cancer. Expert Opinion on Pharmacotherapy, 10(14), pp. 2387-2390.

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Abstract

Background: Zoledronic acid is used to prevent the bone loss associated with antioestrogen treatments in subjects with breast cancer. Preclinical studies suggest that zoledronic acid may have anticancer activity in its own right. This anticancer possibility with zoledronic acid has not been investigated extensively in clinical trials. Objectives/methods: This evaluation is of a large clinical trial that investigated the effect of zoledronic acid on cancer outcomes in premenopausal women with breast cancer. Results: The trial showed that after 4 years, 94.0% of subjects who were treated with zoledronic acid were disease-free compared with 90.8% of those not treated with zoledronic acid. Recurrence survival was a secondary end point; this occurred in 94.0% with, and 90.9% without, zoledronic acid treatment. Conclusions: Zoledronic acid does have anticancer activity in premenopausal women with cancer.

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ID Code: 29669
Item Type: Journal Article
Keywords: zoledronic acid, breast cancer, anticancer, clinical trial
DOI: 10.1517/14656560903173245
ISSN: 1465-6566
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > PHARMACOLOGY AND PHARMACEUTICAL SCIENCES (111500) > Clinical Pharmacology and Therapeutics (111502)
Divisions: Past > QUT Faculties & Divisions > Faculty of Science and Technology
Copyright Owner: Copyright 2009 Informa Healthcare
Deposited On: 14 Jan 2010 08:33
Last Modified: 19 Jan 2012 15:38

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