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Clinical efficacy and safety of zoledronic acid in prostate and breast cancer

Doggrell, Sheila (2009) Clinical efficacy and safety of zoledronic acid in prostate and breast cancer. Expert Review of Anticancer Therapy, 9(9), pp. 1211-1218.

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Abstract

The anti-estrogen treatment for hormone-sensitive breast cancer and the androgen deprivation therapy for prostate cancer can lead to the development of osteoporosis and bone fractures. Metastases associated with prostate and breast cancer can also occur in bone. Bisphosphonates are used in these types of bone dysfunction. Zoledronic acid is the most potent bisphosphonate. In osteoporosis, zoledronic acid inhibits bone reabsorption and increases bone mineral density for at least a year after intravenous administration. The efficacy and safety of zoledronic acid in osteoporosis secondary to hormone-sensitive cancers (prostate and breast), and in the bone metastases associated with these cancers are reviewed.

Impact and interest:

10 citations in Scopus
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7 citations in Web of Science®

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243 since deposited on 13 Jan 2010
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ID Code: 29671
Item Type: Journal Article
Additional URLs:
Keywords: zoledronic acid, bone metastases, breast cancer, osteoporosis, prostate cancer
DOI: 10.1586/era.09.95
ISSN: 1473-7140
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > PHARMACOLOGY AND PHARMACEUTICAL SCIENCES (111500) > Clinical Pharmacology and Therapeutics (111502)
Divisions: Past > QUT Faculties & Divisions > Faculty of Science and Technology
Copyright Owner: Copyright 2009 Expert Reviews Ltd.
Deposited On: 14 Jan 2010 08:10
Last Modified: 19 Jan 2012 15:38

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