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CTA1-DD is an effective adjuvant for targeting anti-chlamydial immunity to the murine genital mucosa

Cunningham, Kelly A., Carey, Alison J., Lycke, Nils, Timms, Peter, & Beagley, Kenneth W. (2009) CTA1-DD is an effective adjuvant for targeting anti-chlamydial immunity to the murine genital mucosa. Journal of Reproductive Immunology, 81(1), pp. 34-38.

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Abstract

Chlamydia trachomatis is a significant human pathogen with potentially severe disease sequelae in the genital tract, including infertility. A successful vaccine will need to effectively target immunity to the genital mucosa. Intranasal immunisation with cholera toxin (CT) can target immunity to the genital tract, but has the potential to cause neurological side effects. CTA1-DD is a non-toxic potent mucosal adjuvant which combines the enzymatic properties of CT, with a B cell targeting moiety. Here, we demonstrate that intranasal immunisation with CTA1-DD and chlamydial Major Outer Membrane Protein (MOMP) results in the induction of neutralising systemic and mucosal antibodies, and reduces the level of chlamydial shedding following intravaginal challenge with Chlamydia muridarum. Thus, CTA1-DD is an effective adjuvant for vaccine development against Chlamydia trachomatis, and possibly also a range of other genital pathogens.

Impact and interest:

21 citations in Scopus
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19 citations in Web of Science®

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ID Code: 30260
Item Type: Journal Article
Keywords: Adjuvant, Chlamydia, Vaccine, STD, CTA1-DD, Mucosal adjuvant
DOI: 10.1016/j.jri.2009.04.002
ISSN: 0165-0378
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > CLINICAL SCIENCES (110300) > Venereology (110324)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > IMMUNOLOGY (110700) > Immunology not elsewhere classified (110799)
Divisions: Past > QUT Faculties & Divisions > Faculty of Science and Technology
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 09 Feb 2010 17:24
Last Modified: 01 Mar 2012 13:30

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