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Poly-immunoglobulin receptor-mediated transport of IgA into the male genital tract is important for clearance of chlamydia muridarum infection

Cunningham, Kelly A., Carey, Alison J., Finnie, Jane M. , Bao, Shisan , Coon, Charmere , Jones, Russell , Wijburg, Odilia , Strugnell, Richard A. , Timms, Peter, & Beagley, Kenneth W. (2008) Poly-immunoglobulin receptor-mediated transport of IgA into the male genital tract is important for clearance of chlamydia muridarum infection. American Journal Of Reproductive Immunology, 60(5), pp. 405-414.

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Abstract

Problem: Chlamydia trachomatis is the most common sexually transmitted infection worldwide. While infection in females requires a Th1 response for clearance, such a response in males may disrupt the immune privileged nature of the male reproductive tract, potentially contributing to infertility.

Method of study: We investigated the role of IgA in protection against an intrapenile Chlamydia muridarum infection of C57BL/6 and pIgR−/− mice.

Results: Here, we show that the poly immunoglobulin receptor is the main pathway for IgA transport into the male reproductive tract. The high levels of IgA seen in prostatic fluid of wild-type mice correlate with reduction in chlamydial infection both in vitro and in vivo.

Conclusion: These findings indicate that a Chlamydia vaccine that induces neutralizing IgA in the prostate will aid in the protection against infection in males.

Impact and interest:

6 citations in Scopus
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6 citations in Web of Science®

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ID Code: 30267
Item Type: Journal Article
Additional URLs:
Keywords: Chlamydia , IgA , Poly-Immunoglobulin Receptor
DOI: 10.1111/j.1600-0897.2008.00637.x
ISSN: 1046-7408
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > IMMUNOLOGY (110700) > Immunology not elsewhere classified (110799)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > CLINICAL SCIENCES (110300) > Infectious Diseases (110309)
Divisions: Past > QUT Faculties & Divisions > Faculty of Science and Technology
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 08 Feb 2010 08:20
Last Modified: 29 Feb 2012 23:49

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