A review of the economic consequences of a policy of universal leucodepletion as compared to existing practices

Clare, Virginia Mary (2009) A review of the economic consequences of a policy of universal leucodepletion as compared to existing practices. PhD thesis, Queensland University of Technology.


Leucodepletion, the removal of leucocytes from blood products improves the safety of blood transfusion by reducing adverse events associated with the incidental non-therapeutic transfusion of leucocytes. Leucodepletion has been shown to have clinical benefit for immuno-suppressed patients who require transfusion. The selective leucodepletion of blood products by bed side filtration for these patients has been widely practiced. This study investigated the economic consequences in Queensland of moving from a policy of selective leucodepletion to one of universal leucodepletion, that is providing all transfused patients with blood products leucodepleted during the manufacturing process. Using an analytic decision model a cost-effectiveness analysis was conducted. An ICER of $16.3M per life year gained was derived. Sensitivity analysis found this result to be robust to uncertainty in the parameters used in the model. This result argues against moving to a policy of universal leucodepletion. However during the course of the study the policy decision for universal leucodepletion was made and implemented in Queensland in October 2008. This study has concluded that cost-effectiveness is not an influential factor in policy decisions regarding quality and safety initiatives in the Australian blood sector.

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ID Code: 30329
Item Type: QUT Thesis (PhD)
Supervisor: Graves, Nicholas
Keywords: blood transfusion, buffy coat poor, leucodepletion, universal leucodepletion, selective leucodepletion, cost-effectiveness, sensitivity analysis, incremental cost-effectiveness ratio, ICER
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Schools > School of Public Health & Social Work
Institution: Queensland University of Technology
Deposited On: 09 Feb 2010 05:13
Last Modified: 28 Oct 2011 19:55

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