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Microassembly fabrication of tissue engineering scaffolds with customized design

Zhang, Han, Burdet, Etienne, Poo, Aun, & Hutmacher, Dietmar (2008) Microassembly fabrication of tissue engineering scaffolds with customized design. IEEE Transactions on Automation Science and Engineering, 5(3), pp. 446-456.

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Abstract

Browse > Journals> Automation Science and Enginee ...> Volume: 5 Issue: 3

Microassembly Fabrication of Tissue Engineering Scaffolds With Customized Design 4468741 abstract
Han Zhang; Burdet, E.; Poo, A.N.; Hutmacher, D.W.;
GE Global Res. Center Ltd., Shanghai

This paper appears in: Automation Science and Engineering, IEEE Transactions on Issue Date: July 2008 Volume: 5 Issue:3 On page(s): 446 - 456 ISSN: 1545-5955 Digital Object Identifier: 10.1109/TASE.2008.917011
Date of Current Version: 02 July 2008 Sponsored by: IEEE Robotics and Automation Society

Abstract This paper presents a novel technique to fabricate scaffold/cell constructs for tissue engineering by robotic assembly of microscopic building blocks (of volume 0.5$,times,$0.5$,times,$0.2 ${hbox{mm}}^{3}$ and 60 $mu {hbox{m}}$ thickness). In this way, it becomes possible to build scaffolds with freedom in the design of architecture, surface morphology, and chemistry. Biocompatible microparts with complex 3-D shapes were first designed and mass produced using MEMS techniques. Semi-automatic assembly was then realized using a robotic workstation with four degrees of freedom integrating a dedicated microgripper and two optical microscopes. Coarse movement of the gripper is determined by pattern matching in the microscopes images, while the operator controls fine positioning and accurate insertion of the microparts. Successful microassembly was demonstrated using SU-8 and acrylic resin microparts. Taking advantage of parts distortion and adhesion forces, which dominate at micro-level, the parts cleave together after assembly. In contrast to many current scaffold fabrication techniques, no heat, pressure, electrical effect, or toxic chemical reaction is involved, a critical condition for creating scaffolds with biological agents.

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14 citations in Web of Science®

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ID Code: 30886
Item Type: Journal Article
Keywords: Microassembly, Microrobotics, Scaffold, Tissue Engineering
DOI: 10.1109/tase.2008.917011
ISSN: 1545-5955
Subjects: Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Biomaterials (090301)
Divisions: Past > QUT Faculties & Divisions > Faculty of Built Environment and Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 12 Feb 2010 22:49
Last Modified: 29 Feb 2012 23:50

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