Critical Oxygen Requirements to Avoid Oedema of the Central and Peripheral Cornea

Brennan, Noel A., Efron, Nathan, & Carney, Leo G. (1987) Critical Oxygen Requirements to Avoid Oedema of the Central and Peripheral Cornea. Acta Ophthalmologica, 65(5), pp. 556-564.


A randomized double-masked experiment was performed to compare the critical oxygen concentrations required to avoid corneal thickening at the central and peripheral cornea. Pachometry was performed on 10 subjects before and after 3 h of corneal exposure to the following gasmixtures: 0.00, 1.01, 2.65, 5.13 and 10.3% oxygen, balance nitrogen. Widely ranging critical values (from 4.4 to 11.6% for the central cornea and 1.7 to 15.8% for the peripheral cornea) could be obtained depending upon the analytical procedure used to treat the data; that is, the choice of reference baseline, the curve fitting procedure adopted and the method of comparing the reference baseline with the fitted curve. The estimates of the critical oxygen requirement of the central cornea are consistent with previous studies when compared using the same analytical procedure. Similar critical values were derived for the central and peripheral cornea for any given analytical procedure (e.g. 9.8% for the central cornea, and 12.3% for the peripheral cornea for zero mean change in corneal thickness). Our findings indicate that anatomical and physiological differences between the central and peripheral cornea do not have clinically significant effects on the minimum oxygen requirements at these respective sites. This result has implications with respect to lens design considerations for alleviating physiological stress of the cornea during contact lens wear.

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18 citations in Scopus
10 citations in Web of Science®
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ID Code: 3092
Item Type: Journal Article
Refereed: Yes
Additional Information: For more information, please refer to the journal's website (see link) or contact the author. Author contact details:
Additional URLs:
Keywords: Oxygen, Corneal Diseases, prevention & control, Edema, prevention & control, Adult Anoxia Clinical Trials, Corneal Diseases, etiology, Edema etiology, Female, Humans, Male, Random Allocation, Regression Analysis, Research Support, Non, U, S, Government
ISSN: 1395-3907
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 1987 Blackwell Publishing
Copyright Statement: The definitive version is available at
Deposited On: 19 Jan 2006 00:00
Last Modified: 10 Aug 2011 13:21

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