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In vitro and in vivo analysis of co-electrospun scaffolds made of medical grade poly(epsilon-caprolactone) and porcine collagen

Chen, Z.C., Ekaputra, A. K., Gauthaman, K., Adaikan, P.G., Yu, H., & Hutmacher, D. W. (2008) In vitro and in vivo analysis of co-electrospun scaffolds made of medical grade poly(epsilon-caprolactone) and porcine collagen. Journal of Biomaterials Science (Polymer Edition), 19(5), pp. 693-707.

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Abstract

In this study, a nanofiber mesh made by co-electrospinning medical grade poly(epsilon-caprolactone) and collagen (mPCL/Col) was fabricated and studied. Its mechanical properties and characteristics were analyzed and compared to mPCL meshes. mPCL/Col meshes showed a reduction in strength but an increase in ductility when compared to PCL meshes. In vitro assays revealed that mPCL/Col supported the attachment and proliferation of smooth muscle cells on both sides of the mesh. In vivo studies in the corpus cavernosa of rabbits revealed that the mPCL/Col scaffold used in conjunction with autologous smooth muscle cells resulted in better integration with host tissue when compared to cell free scaffolds. On a cellular level preseeded scaffolds showed a minimized foreign body reaction.

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17 citations in Scopus
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14 citations in Web of Science®

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ID Code: 31019
Item Type: Journal Article
Keywords: Cell Proliferation, Nanotechnology , Cell Adhesion
DOI: 10.1163/156856208784089580
ISSN: 0920-5063
Subjects: Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Biomaterials (090301)
Divisions: Past > QUT Faculties & Divisions > Faculty of Built Environment and Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Past > Schools > School of Engineering Systems
Deposited On: 22 Feb 2010 07:59
Last Modified: 29 Feb 2012 23:50

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