Extended contact lens wear in the developing cynomolgus monkey eye: Recovery from adverse responses

Carney, Leo G., Kiely, Patricia M., Brennan, Noel A., Crewther, Sheila G., & Nathan, John (1989) Extended contact lens wear in the developing cynomolgus monkey eye: Recovery from adverse responses. Cornea, 8(3), pp. 182-187.


Soft extended wear contact lenses were designed for and fitted to 12 eyes of 11 infant semiwild cynomolgus monkeys. The lenses were satisfactorily worn over observation periods of up to 465 days, the longest continuous period of lens wear being 69 days. However, some of the corneas were subject to a pattern of complications analogous to that in human contact lens wear. Nine eyes showed adverse responses, and of these, the ocular complications were severe enough in four cases to cause abandonment of lens wear. The most remarkable feature of the complications was the rapid recovery of severe reactions to near normality in less than 24 h, indicating an impressive ability of the cornea to tolerate and survive insult. Another feature was the recurrent nature of mild complications in certain monkeys despite apparent resolution from previous episodes. There appeared to be no correlation between duration of lens wear and appearance of the first or recurrent episodes of corneal infiltration and vascularization.

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2 citations in Scopus
2 citations in Web of Science®
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ID Code: 3128
Item Type: Journal Article
Refereed: Yes
Additional Information: Self-archiving of the author-version is not yet supported by this publisher.
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Keywords: Macaca, Macaca fascicularis, Contact Lenses, Extended, Wear/, adverse effects, Corneal Diseases/, etiology, Age Factors, Animals, Cornea/blood supply, Corneal Diseases/rehabilitation, Corneal Opacity/complications, Edema/complications, Longitudinal Studies, Neovascularization, Pathologic/complications, Research Support, Non, U, S, Gov't, Time Factors
ISSN: 0277-3740
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 1989 Lippincott, Williams & Wilkins
Deposited On: 31 Jan 2006 00:00
Last Modified: 10 Aug 2011 13:21

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