Time course of corneal oxygen uptake during contact lens wear
Carney, Leo G. & Brennan, Noel A. (1988) Time course of corneal oxygen uptake during contact lens wear. The CLAO journal : official publication of the Contact Lens Association of Ophthalmologists, 14(3), pp. 151-154.
We used a polarographic oxygen sensor to measure corneal oxygen uptake rates of 16 subjects during daily wear of soft contact lenses. The subjects reported for examinations on nine occasions over a 30-week lens wearing period. Corneal oxygen uptake rates were measured immediately after lens removal and at 11 additional times over the following 60 minutes. Compared to the pre-fitting (baseline) values, the oxygen uptake rate immediately after contact lens removal was substantially increased early in contact lens wear. It then fell in a nearly stepwise fashion over the 30-week observation period. Whenever measured during the 30-week course of the study oxygen uptake rate decreased rapidly over the first one to two minutes after lens removal. It then showed only minor fluctuations for the remainder of the 60-minute examination. At wearing durations longer than 19 weeks this stable oxygen uptake value was less than the baseline value. We suggest that these changes are a direct consequence of altered epithelial metabolic activity, although possible contributions from instrument drift and corneal thickness changes cannot be discounted.
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|Item Type:||Journal Article|
|Keywords:||Contact Lenses, Oxygen Consumption, Cornea/, metabolism, Adolescent, Adult, Epithelium/metabolism, Female, Humans, Male, Research Support, Non, U, S, Gov't|
|Subjects:||Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300)|
|Divisions:||Current > QUT Faculties and Divisions > Faculty of Health|
Current > Institutes > Institute of Health and Biomedical Innovation
|Copyright Owner:||Copyright 1988 Contact Lens Association of Ophthalmologists|
|Copyright Statement:||Reproduced in accordance with the copyright policy of the publisher.|
|Deposited On:||31 Jan 2006|
|Last Modified:||10 Aug 2011 23:21|
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