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Responses to oxygen deprivation: Variations among human corneas

Fink, Barbara A., Carney, Leo G., & Hill, Richard M. (1991) Responses to oxygen deprivation: Variations among human corneas. Graefe's Archive for Clinical and Experimental Ophthalmology, 229(3), pp. 287-290.

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Abstract

The cornea's interface with the atmosphere makes it uniquely accessible among avascular tissue for the study of local oxygen demand and proximal reservoir dynamics. Corneal oxygen-uptake rates obtained under normoxic vs hypoxic conditions are not predictive of each other. Proximal tissue reservoirs appear to play a role in moderating oxygen demands following periods of hypoxic stress: as the ratio of epithelia/stromal thickness rises, so does oxygen demand (r = +0.932, P = 0.01). The thickness of the stroma was most closely related to the oxygen uptake rates associated with the normal, open eye (r = +0.773, P = 0.07), whereas the thickness of the epithelium was more closely related to rates obtained after the cornea had been deprived of oxygen (r = +0.783, P = 0.07).

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8 citations in Scopus
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5 citations in Web of Science®

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ID Code: 3141
Item Type: Journal Article
Additional Information: For more information, please refer to the journal’s website (see link) or contact the author. Author contact details: l.carney@qut.edu.au
Keywords: Cornea/, metabolism, Oxygen/, pharmacokinetics, Adult, Cornea/anatomy & histology, Corneal Stroma/anatomy & histology, Epithelium/anatomy & histology, Humans, Microelectrodes, Oxygen Consumption, Research Support, U, S, Gov't, P, H, S
DOI: 10.1007/BF00167886
ISSN: 1435-702X
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 1991 Springer
Copyright Statement: The original publication is available at SpringerLink http://www.springerlink.com
Deposited On: 31 Jan 2006
Last Modified: 15 Jan 2009 16:54

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