Latitude variation in pancreatic cancer mortality in Australia

Neale, Rachel E., Youlden, Danny R., Krnjacki, Lauren J., Kimlin, Michael G., & van der Pols, Jolieke C. (2009) Latitude variation in pancreatic cancer mortality in Australia. Pancreas, 38(4), pp. 387-390.

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Objectives: Ecological studies support the hypothesis that there is an association between vitamin D and pancreatic cancer (PaCa) mortality, but observational studies are somewhat conflicting. We sought to contribute further data to this issue by analyzing the differences in PaCa mortality across the eastern states of Australia and investigating if there is a role of vitamin D-effective ultraviolet radiation (DUVR), which is related to latitude.

Methods: Mortality data from 1968 to 2005 were sourced from the Australian General Record of Incidence and Mortality books. Negative binomial models were fitted to calculate the association between state and PaCa mortality. Clear sky monthly DUVR in each capital city was also modeled.

Results: Mortality from PaCa was 10% higher in southern states than in Queensland, with those in Victoria recording the highest mortality risk (relative risk, 1.13; 95% confidence interval, 1.09-1.17). We found a highly significant association between DUVR and PaCa mortality, with an estimated 1.5% decrease in the risk per 10-kJ/m2 increase in yearly DUVR.

Conclusions: These data show an association between latitude, DUVR, and PaCa mortality. Although this study cannot be used to infer causality, it supports the need for further investigations of a possible role of vitamin D in PaCa etiology.

Impact and interest:

19 citations in Scopus
13 citations in Web of Science®
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ID Code: 31413
Item Type: Journal Article
Refereed: Yes
Additional URLs:
Keywords: Pancreatic Neoplasms, Mortality, Vitamin D, Ecological
DOI: 10.1097/MPA.0b013e31819975f4
ISSN: 0885-3177
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > PUBLIC HEALTH AND HEALTH SERVICES (111700) > Epidemiology (111706)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Public Health & Social Work
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Deposited On: 22 Apr 2010 02:18
Last Modified: 28 Apr 2017 04:35

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