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Computational fluid dynamics for improved bioreactor design and 3D culture

Hutmacher, Dietmar W. & Singh, Harmeet (2008) Computational fluid dynamics for improved bioreactor design and 3D culture. Trends in Biotechnology, 26(4), pp. 166-172.

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Abstract

The complex relationship between the hydrodynamic environment and surrounding tissues directly impacts on the design and production of clinically useful grafts and implants. Tissue engineers have generally seen bioreactors as 'black boxes' within which tissue engineering constructs (TECs) are cultured. It is accepted that a more detailed description of fluid mechanics and nutrient transport within process equipment can be achieved by using computational fluid dynamics (CFD) technology. This review discusses applications of CFD for tissue engineering-related bioreactors -- fluid flow processes have direct implications on cellular responses such as attachment, migration and proliferation. We conclude that CFD should be seen as an invaluable tool for analyzing and visualizing the impact of fluidic forces and stresses on cells and TECs.

Impact and interest:

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52 citations in Web of Science®

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ID Code: 31432
Item Type: Journal Article
Additional URLs:
Keywords: Cell Adhesion, Cell Proliferation, Computer Simulation, Tissue Engineering, Bioreactors
DOI: 10.1016/j.tibtech.2007.11.012
ISSN: 0167-7799
Subjects: Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > BIOCHEMISTRY AND CELL BIOLOGY (060100) > Cellular Interactions (incl. Adhesion Matrix Cell Wall) (060106)
Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > BIOCHEMISTRY AND CELL BIOLOGY (060100) > Cell Development Proliferation and Death (060103)
Australian and New Zealand Standard Research Classification > INFORMATION AND COMPUTING SCIENCES (080000) > ARTIFICIAL INTELLIGENCE AND IMAGE PROCESSING (080100) > Simulation and Modelling (080110)
Divisions: Past > QUT Faculties & Divisions > Faculty of Built Environment and Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Past > Schools > School of Engineering Systems
Copyright Owner: Copyright 2008 Elsevier Ltd.
Deposited On: 25 May 2010 14:47
Last Modified: 29 Feb 2012 23:50

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