Intra-subject Variability of Human Corneal Oxygen Uptake

Fink, Barbara A., Carney, Leo G., & Hill, Richard M. (1990) Intra-subject Variability of Human Corneal Oxygen Uptake. International Contact Lens Clinic, 17, pp. 224-227.


The repeatability for measurement of corneal oxygen uptake for six human corneas, observed over the course of 3 years, was analysed. A total of 48 measurements, collected on three separate occasions, were completed on each cornea: 24 under normal open eye conditions and 24 under controlled hypoxic conditions. Repeatability was evaluated for the non-stressed, open eye condition, for hypoxic condition, and for the hypoxic data relativized to the normal open eye data. Significant differences were found between the subjects for the normal open eye condition, the hypoxic condition and the relativized data. Differences found between measurement periods were significant for the unstressed and hypoxic conditions in absolute units, but not for their relativised form. By referencing oxygen uptake data obtained under test conditions to that obtained for the normal open eye, differences due to instrument and corneal instabilities become statistically insignificant and inter-subject variability differences become more apparent.

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ID Code: 3151
Item Type: Journal Article
Refereed: Yes
Additional Information: For more information, please refer to the journal's website (see link) or contact the author. Author contact details:
Additional URLs:
Keywords: hypoxia, oxygen uptake
ISSN: 0892-8967
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 1990 Elsevier
Deposited On: 31 Jan 2006 00:00
Last Modified: 15 Jan 2009 06:54

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