Effect of topical anaesthesia on corneal epithelial fragility
The effect of topical anaesthetics on human corneal integrity was assessed by measurement of the alterations they cause in corneal damage threshold. The anaesthetics investigated were 1.0% Amethocaine HCl, assessed immediately after instillation and after delays of 20 min and 60 min, and 0.5% Amethocaine HCl and 0.4% Benoxinate HCl, assessed 20 min after instillation. At 20 min after instillation of 1.0% Amethocaine HCl, the corneal damage threshold was significantly decreased. At other times for this anaesthetic, and for 0.5% Amethocaine HCl and 0.4% Benoxinate HCl, the corneal damage threshold was unaltered.
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|Item Type:||Journal Article|
|Additional Information:||For more information, please refer to the journal’s website (see link) or contact the author. Author contact details: firstname.lastname@example.org|
|Keywords:||Anesthetics, Local/, toxicity, Cornea/, drug effects, Procaine/, analogs & derivatives, Tetracaine/, toxicity, Epithelium/drug effects, Humans, Procaine/toxicity, Time Factors|
|Subjects:||Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300)|
|Divisions:||Current > QUT Faculties and Divisions > Faculty of Health|
|Copyright Owner:||Copyright 1984 Springer|
|Copyright Statement:||The original publication is available at SpringerLink http://www.springerlink.com|
|Deposited On:||30 Jan 2006|
|Last Modified:||15 Jan 2009 16:54|
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