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Bioactive mesopore-glass microspheres with controllable protein-delivery properties by biomimetic surface modification

Wu, Chengtie, Zhang, Yufeng, Ke, Xuebin, Zhu, Huai Yong, Crawford, Ross W., & Xiao, Yin (2010) Bioactive mesopore-glass microspheres with controllable protein-delivery properties by biomimetic surface modification. Journal of Biomedical Materials Research Part A, 95A(2), pp. 476-485.

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Abstract

Microsphere systems with the ideal properties for bone regeneration need to be bioactive, and at the same time possess the capacity for controlled protein/drug-delivery; however, the current crop of microsphere system fails to fulfill these properties. The aim of this study was to develop a novel protein-delivery system of bioactive mesoporous glass (MBG) microspheres by a biomimetic method through controlling the density of apatite on the surface of microspheres, for potential bone tissue regeneration. MBG microspheres were prepared by using the method of alginate cross-linking with Ca2+ ions. The cellular bioactivity of MBG microspheres was evaluated by investigating the proliferation and attachment of bone marrow stromal cell (BMSC). The loading efficiency and release kinetics of bovine serum albumin (BSA) on MBG microspheres were investigated after coprecipitating with biomimetic apatite in simulated body fluids (SBF). The results showed that MBG microspheres supported BMSC attachment and the Si containing ionic products from MBG microspheres stimulated BMSCs proliferation. The density of apatite on MBG microspheres increased with the length of soaking time in SBF. BSA-loading efficiency of MBG was significantly enhanced by co-precipitating with apatite. Furthermore, the loading efficiency and release kinetics of BSA could be controlled by controlling the density of apatite formed on MBG microspheres. Our results suggest that MBG microspheres are a promising protein-delivery system as a filling material for bone defect healing and regeneration.

Impact and interest:

24 citations in Scopus
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21 citations in Web of Science®

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ID Code: 32016
Item Type: Journal Article
Additional URLs:
DOI: 10.1002/jbm.a.32873
ISSN: 1549-3296
Divisions: Current > Schools > School of Curriculum
Past > QUT Faculties & Divisions > Faculty of Built Environment and Engineering
Past > QUT Faculties & Divisions > Faculty of Science and Technology
Current > Institutes > Institute of Health and Biomedical Innovation
Past > Schools > School of Engineering Systems
Copyright Owner: Copyright 2010 John Wiley & Sons
Copyright Statement: The definitive version is available at www3.interscience.wiley.com
Deposited On: 28 Apr 2010 09:39
Last Modified: 07 Nov 2013 08:19

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